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Characterization of the immunomodulatory and anti-Helicobacter pylori properties of the human gastric isolate Lactobacillus rhamnosus UCO-25A.
Garcia-Castillo, Valeria; Marín-Vega, Ana María; Ilabaca, Alejandra; Albarracín, Leonardo; Marcial, Guillermo; Kitazawa, Haruki; Garcia-Cancino, Apolinaria; Villena, Julio.
Afiliação
  • Garcia-Castillo V; Laboratory of Bacterial Pathogenicity, Faculty of Biological Sciences, University of Concepcion, Concepcion, Chile.
  • Marín-Vega AM; Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina.
  • Ilabaca A; Food and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
  • Albarracín L; Food and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
  • Marcial G; Laboratory of Bacterial Pathogenicity, Faculty of Biological Sciences, University of Concepcion, Concepcion, Chile.
  • Kitazawa H; Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina.
  • Garcia-Cancino A; Food and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
  • Villena J; Laboratory of Computing Science, Faculty of Exact Sciences and Technology, Tucuman University, Tucuman, Argentina.
Biofouling ; 35(8): 922-937, 2019 09.
Article em En | MEDLINE | ID: mdl-31646895
The ability to form biofilms and the potential immunomodulatory properties of the human gastric isolate Lactobacillus rhamnosus UCO-25A were characterized in vitro. It was demonstrated that L. rhamnosus UCO-25A is able to form biofilms on abiotic and cell surfaces, and to modulate the inflammatory response triggered by Helicobacter pylori infection in gastric epithelial cells and THP-1 macrophages. L. rhamnosus UCO-25A exhibited a substantial anti-inflammatory effect in both cell lines and improved IL-10 levels produced by challenged macrophages. Additionally, UCO-25A protected AGS cells against H. pylori infection with a higher pathogen inhibition when a biofilm was formed. Given the importance of inflammation in H. pylori-mediated diseases, the differential modulation of the inflammatory response in the gastric mucosa by an autochthonous strain is an attractive alternative for improving H. pylori eradication and reducing the severity of the diseases that arise from the resulting chronic inflammation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Helicobacter pylori / Biofilmes / Probióticos / Células Epiteliais / Lacticaseibacillus rhamnosus / Fatores Imunológicos / Macrófagos Limite: Humans Idioma: En Revista: Biofouling Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Helicobacter pylori / Biofilmes / Probióticos / Células Epiteliais / Lacticaseibacillus rhamnosus / Fatores Imunológicos / Macrófagos Limite: Humans Idioma: En Revista: Biofouling Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido