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BRAFV600E and KIT immunoexpression in early-stage melanoma.
Germano, Andressa; Cardili, Leonardo; Carapeto, Fernando Cintra Lopes; Landman, Gilles.
Afiliação
  • Germano A; Graduate Studies Program in Pathology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Cardili L; Department of Pathology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Carapeto FCL; Graduate Studies Program in Pathology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Landman G; Department of Pathology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
An Bras Dermatol ; 94(4): 458-460, 2019.
Article em En | MEDLINE | ID: mdl-31644622
Melanoma is widely known as the most lethal skin cancer. Specific tumor-related mortality can be significantly reduced if diagnosis and treatment are properly performed during initial phases of the disease. The current search for biomarkers in early-stage melanomas is a high-priority challenge for physicians and researchers. We aimed to assess the immunoexpression of BRAFV600E and KIT in a case series consisting of 44 early-stage melanomas. Formalin-fixed paraffin-embedded samples were systematically evaluated using a semi-quantitative method based on scores of percentage and intensity for immunostained tumor cells. We observed significant concordance between BRAFV600E and KIT immunoexpression in thin invasive melanomas. Our findings corroborate previous evidence showing abnormal expression of proteins associated with MAPK intracellular signaling pathway in early-stage melanomas.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Proteínas Proto-Oncogênicas c-kit / Proteínas Proto-Oncogênicas B-raf / Melanoma Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: An Bras Dermatol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Espanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Proteínas Proto-Oncogênicas c-kit / Proteínas Proto-Oncogênicas B-raf / Melanoma Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: An Bras Dermatol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Espanha