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Sex differences in adult zebrafish anxiolytic-like responses to diazepam and melatonin.
Genario, Rafael; Giacomini, Ana C V V; de Abreu, Murilo S; Marcon, Leticia; Demin, Konstantin A; Kalueff, Allan V.
Afiliação
  • Genario R; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
  • Giacomini ACVV; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Postgraduate Program in Environmental Sciences, University of Passo Fundo (UPF), Passo Fundo, Brazil.
  • de Abreu MS; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA. Electronic address: abreu_murilo@hotmail.com.
  • Marcon L; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
  • Demin KA; Institute of Experimental Medicine, Almazov Medical Research Center, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
  • Kalueff AV; School of Pharmacy, Southwest University, Chongqing, China; Ural Federal University, Ekaterinburg, Russia; Granov Scientific Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation St. Petersburg, Russia. Electronic address: avkalueff@gmail.com.
Neurosci Lett ; 714: 134548, 2020 01 01.
Article em En | MEDLINE | ID: mdl-31629774
Sex differences are an important variable in biomedical research. The zebrafish (Danio rerio) is rapidly becoming a critical novel model organism in translational neuroscience and neuropharmacology. Here, we examine the effects of sex on locomotor activity and anxiety-like behavior in adult zebrafish tested in the novel tank test following their exposure to two clinically relevant, common anxiolytic drugs diazepam and melatonin. While control female zebrafish were more active and anxious than males, both sexes showed anxiolytic responses to melatonin (0.232 mg/L) but only males responded to diazepam (16 µg/L). Revealing sex specificity in pharmacological responses, this study emphasizes the importance of sex differences in behavioral and pharmacological analyses in zebrafish. This may also be potentially relevant to modeling sex differences in clinical responses to anxiolytic drugs. Collectively, our data support sex differences in zebrafish behavioral responses and reinforce the growing utility of this aquatic model in CNS drug screening.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Caracteres Sexuais / Diazepam / Melatonina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Caracteres Sexuais / Diazepam / Melatonina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda