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Oxidative stress in hepatitis C virus-human immunodeficiency virus co-infected patients.
Gravier-Hernández, Rosario; Gil-Del Valle, Lizette; Valdes-Alonso, Lindunka; Hernández-Ayala, Nadiecha; Bermúdez-Alfonso, Yusimit; Hernández-Requejo, Daymé; Rosell-Guerra, Teresa; Hernández-González-Abreu, Maria C.
Afiliação
  • Gravier-Hernández R; Institute "Pedro Kourí" (IPK), Havana, Cuba.
  • Gil-Del Valle L; Institute "Pedro Kourí" (IPK), Havana, Cuba. Electronic address: lgil@ipk.sld.cu.
  • Valdes-Alonso L; Institute "Pedro Kourí" (IPK), Havana, Cuba.
  • Hernández-Ayala N; Institute of Pharmacy and Food, Havana University, Cuba.
  • Bermúdez-Alfonso Y; Institute "Pedro Kourí" (IPK), Havana, Cuba.
  • Hernández-Requejo D; Institute "Pedro Kourí" (IPK), Havana, Cuba.
  • Rosell-Guerra T; Institute "Pedro Kourí" (IPK), Havana, Cuba.
  • Hernández-González-Abreu MC; Institute "Pedro Kourí" (IPK), Havana, Cuba.
Ann Hepatol ; 19(1): 92-98, 2020.
Article em En | MEDLINE | ID: mdl-31607646
INTRODUCTION AND OBJECTIVES: Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) co-infection generates sustained inflammation with increased reactive oxygen species production. The pathogenic impact of systemic oxidative stress is known to influence drug treatment and follow-up. The aim of this case-control study was to compare the redox status in HCV-HIV co-infected with respect to HIV-infected individuals and to explore the relation between redox and HIV follow-up variables. PATIENTS OR MATERIALS AND METHODS: Blood samples were drawn from 330 individuals divided into three groups: HIV, HCV-HIV and presumable healthy subjects. Redox, hematological, hemochemical, immunologic and virological indexes were determined. RESULTS: Both HIV groups had significant differences in global indexes of damage and antioxidant status (p<0.05) with respect to the supposedly healthy individual group. HCV-HIV group showed a significantly higher damage (total hydroperoxide and advanced oxidation protein products) compared to the control and HIV groups (p<0.05). The overall modification of the redox indexes showed that 72% of individuals with simultaneous detrimental differences were related to HCV-HIV condition. CONCLUSIONS: These results corroborate that oxidative stress occurs in the HIV condition and also during HCV-HIV co-infection, with different molecular changes of follow-up indexes. Redox indexes diagnosis should be considered in early diagnosis and treatment of HCV-HIV co-infection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Estresse Oxidativo / Hepatite C Crônica Tipo de estudo: Observational_studies / Risk_factors_studies / Screening_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Cuba País de publicação: México
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Estresse Oxidativo / Hepatite C Crônica Tipo de estudo: Observational_studies / Risk_factors_studies / Screening_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Cuba País de publicação: México