Azithromycin and Full-Mouth Scaling For the Treatment of Generalized Stage III and IV Periodontitis: A 6-Month Randomized Comparative Clinical Trial.

Oliveira, Alcione M S D; Costa, Fernando O; Nogueira, Letícia Mara R; Cortelli, Sheila C; Oliveira, Peterson A D; Aquino, Davi R; Miranda, Taís B; Cortelli, José R

Oliveira, Alcione M S D; Costa, Fernando O; Nogueira, Letícia Mara R; Cortelli, Sheila C; Oliveira, Peterson A D; Aquino, Davi R; Miranda, Taís B; Cortelli, José R.

Afiliação

Oliveira AMSD; Periodontal Department, Dental School, PUC - Pontifícia Universidade Católica de Minas Gerais, Belo Horizonte, MG, Brazil.
Costa FO; Periodontal Department, Dental School, UFMG - Universidade Federal de Minas Gerais, MG, Belo Horizonte, Brazil.
Nogueira LMR; Dental School, UNITAU - Universidade de Taubaté, Taubaté, SP, Brazil.
Cortelli SC; Nucleus of Periodontal Tesearch, Dental School, UNITAU - Universidade de Taubaté, Taubaté, SP, Brazil.
Oliveira PAD; Periodontal Department, Dental School, PUC - Pontifícia Universidade Católica de Minas Gerais, Belo Horizonte, MG, Brazil.
Aquino DR; Nucleus of Periodontal Tesearch, Dental School, UNITAU - Universidade de Taubaté, Taubaté, SP, Brazil.
Miranda TB; Dental School, UNITAU - Universidade de Taubaté, Taubaté, SP, Brazil.
Cortelli JR; Nucleus of Periodontal Tesearch, Dental School, UNITAU - Universidade de Taubaté, Taubaté, SP, Brazil.

Braz Dent J ; 30(5): 429-436, 2019.

Article em En | MEDLINE | ID: mdl-31596326

RESUMO

The effectiveness of azithromycin combined with full-mouth scaling procedures was compared to quadrant-wise scaling combined with the same dosage of azithromycin when treating periodontitis patients over a 6-month period. In this randomized clinical trial study, thirty-four individuals diagnosed with generalized stage III and IV periodontitis underwent baseline, 3-month, and 6-month post-treatment examinations. The study population was randomly assigned to either full-mouth scaling (FMS) or quadrant-wise scaling and root planning (QSRP) in addition to their taking of systemic azithromycin (500 mg/day) for three consecutive days. Periodontal probing depth (PD), clinical attachment level (CAL), gingival index (GI), and plaque index (PI) were monitored along with the quantification of total bacterial load and red complex bacterial species (Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola) in subgingival samples by real time polymerase chain reaction. The volume of gingival crevicular fluid (GCF) was also monitored over time. The primary outcomes included improvements of PD and CAL. Data was statistically analyzed through a repeated-measures analysis of variance (ANOVA) test, multiple least significant difference (LSD) comparisons, Kruskal-Wallis, Friedman, and paired Student t-tests (p<0.05). FMS and QSRP provided similar PD, CAL, GI, PI, and GCF improvements. After treatment, the FMS group displayed lower mean values of total bacterial load and red complex bacterial species in comparison to the QSRP group. FMS and QSRP in conjunction with systemic azithromycin appeared to be an effective and reliable short-term therapeutic approach for the treatment of generalized stage III and IV periodontitis. However, FMD demonstrated superiority in regard to the 6-month antibacterial effects when compared to QSRP.

Assuntos

Azitromicina; Periodontite; Antibacterianos; Raspagem Dentária; Seguimentos; Líquido do Sulco Gengival; Humanos; Perda da Inserção Periodontal; Aplainamento Radicular

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Periodontite / Azitromicina Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Braz Dent J Assunto da revista: ODONTOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

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