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Molluscicidal and cercaricidal activities of curcumin on Biomphalaria glabrata and Schistosoma mansoni cercariae.
Matos, Jaqueline L; da Silva, Karen R; de Lima Paula, Lucas A; Cunha, Wilson R; Ramos, Salvador B; Rodrigues, Vanderlei; Cabral, Fernanda J; Magalhães, Lizandra G.
Afiliação
  • Matos JL; Research Group on Natural Products, Center for Research in Sciences and Technology, University of Franca, Franca, Brazil.
  • da Silva KR; Research Group on Natural Products, Center for Research in Sciences and Technology, University of Franca, Franca, Brazil.
  • de Lima Paula LA; Research Group on Natural Products, Center for Research in Sciences and Technology, University of Franca, Franca, Brazil.
  • Cunha WR; Research Group on Natural Products, Center for Research in Sciences and Technology, University of Franca, Franca, Brazil.
  • Ramos SB; Department of Health Promotion, University of Franca, Franca, Brazil.
  • Rodrigues V; Department of Biochemistry and Immunology, College of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
  • Cabral FJ; Department of Animal Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
  • Magalhães LG; Research Group on Natural Products, Center for Research in Sciences and Technology, University of Franca, Franca, Brazil.
Pest Manag Sci ; 76(4): 1228-1234, 2020 Apr.
Article em En | MEDLINE | ID: mdl-31587497
BACKGROUND: Schistosomiasis control in endemic areas depends on several factors, including chemotherapy, snail control and adequate sanitation. In this context, the employment of compounds isolated from plants is an important issue regarding infection and snail control. The aim of this study was therefore to evaluate the effects of curcumin (CUR), a compound isolated from Curcuma longa, against snails and embryos of Biomphalaria glabrata, which is the most important intermediate host of schistosomiasis in the Americas, as well as in cercariae, the infecting larval stage of Schistosoma mansoni. RESULTS: CUR presented high activity against B. glabrata embryos and moderate activity against newborn and adult snails. The lethal concentration (LC50 ) values after being exposed for 24 h and evaluated for 7 days were 6.54 (95% confidence interval (CI) 5.86-7.30) µg mL-1 for the embryos and 42.29 (95% CI 33.82-52.87) µg mL-1 and 87.69 (95% CI 68.82-111.7) µg mL-1 for the newborn and adult snails, respectively. Moreover, CUR inhibited the development of embryos and egg hatching, and decreased the fecundity rates of adult snails. CUR also demonstrated cercaricidal activity with LC50 values lower than 10 µg mL-1 at 1, 3, 6, 9 and 12 h, respectively. CONCLUSION: Our data show that CUR has potential molluscicidal and cercaricidal activities. Moreover, as a nutraceutical compound that is toxic to both invertebrate host and parasite, CUR has the potential to be explored as a safe new agent to combat schistosomiasis. © 2019 Society of Chemical Industry.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Schistosoma mansoni / Biomphalaria / Moluscocidas Limite: Animals Idioma: En Revista: Pest Manag Sci Assunto da revista: TOXICOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Schistosoma mansoni / Biomphalaria / Moluscocidas Limite: Animals Idioma: En Revista: Pest Manag Sci Assunto da revista: TOXICOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido