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Opposed cannabinoid 1 receptor (CB1R) expression in the prefrontal cortex vs. nucleus accumbens is associated with alcohol consumption in male rats.
Amancio-Belmont, Octavio; Becerril Meléndez, Alline L; Ruiz-Contreras, Alejandra E; Méndez-Díaz, Mónica; Prospéro-García, Oscar.
Afiliação
  • Amancio-Belmont O; Grupo de Neurociencias, Laboratorio de Canabinoides, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico.
  • Becerril Meléndez AL; Grupo de Neurociencias, Laboratorio de Canabinoides, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico.
  • Ruiz-Contreras AE; Grupo de Neurociencias, Laboratorio de Neurogenómica Cognitiva, Departamento de Psicofisiología, Facultad de Psicología, Universidad Nacional Autónoma de México, Mexico.
  • Méndez-Díaz M; Grupo de Neurociencias, Laboratorio de Canabinoides, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico.
  • Prospéro-García O; Grupo de Neurociencias, Laboratorio de Canabinoides, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico. Electronic address: opg@unam.mx.
Brain Res ; 1725: 146485, 2019 12 15.
Article em En | MEDLINE | ID: mdl-31568767
Abusive alcohol consumption is a health problem, worldwide. There is extensive literature indicating that cannabinoid 1 receptor (CB1R) plays a crucial role in mediating alcohol's reward effects. Maternal care deprivation (MCD) is a reliable rodent model of early life stress that leads to high levels of anxiety and alterations in motivation, which may increase vulnerability to alcohol consumption. The present study researched whether anxiety-like behaviors and the level of motivation for a natural reward, and CB1R expression in the prefrontal cortex (PFC) and nucleus accumbens (NAcc) can predict alcohol consumption in non-MCD and MCD male rats. Results indicate that MCD increases anxiety-like behaviors, i.e., reduces time in open arms in the elevated plus maze and increases alcohol intake. In turn, the motivation for a palatable reward, i.e., a chocolate flavored pellet, was not affected by MCD. MCD reduces CB1R expression in the PFC and increases it in the NAcc. Hence, both higher anxiety-like behaviors and higher CB1R expression in the NAcc and lower CB1R expression in the PFC are associated with higher alcohol intake. These results suggest that early life adverse experiences induce a reprogramming of the brain's endocannabinoid system that very likely contributes to making the brain vulnerable to develop alcohol abuse and dependence.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiedade / Recompensa / Consumo de Bebidas Alcoólicas / Córtex Pré-Frontal / Receptor CB1 de Canabinoide / Núcleo Accumbens Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Brain Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiedade / Recompensa / Consumo de Bebidas Alcoólicas / Córtex Pré-Frontal / Receptor CB1 de Canabinoide / Núcleo Accumbens Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Brain Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Holanda