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Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells.
Menares, Evelyn; Gálvez-Cancino, Felipe; Cáceres-Morgado, Pablo; Ghorani, Ehsan; López, Ernesto; Díaz, Ximena; Saavedra-Almarza, Juan; Figueroa, Diego A; Roa, Eduardo; Quezada, Sergio A; Lladser, Alvaro.
Afiliação
  • Menares E; Laboratory of Immunoncology, Fundación Ciencia & Vida, Santiago, Chile.
  • Gálvez-Cancino F; Laboratory of Immunoncology, Fundación Ciencia & Vida, Santiago, Chile.
  • Cáceres-Morgado P; Laboratory of Immunoncology, Fundación Ciencia & Vida, Santiago, Chile.
  • Ghorani E; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.
  • López E; Laboratory of Immunoncology, Fundación Ciencia & Vida, Santiago, Chile.
  • Díaz X; Laboratory of Immunoncology, Fundación Ciencia & Vida, Santiago, Chile.
  • Saavedra-Almarza J; Laboratory of Immunoncology, Fundación Ciencia & Vida, Santiago, Chile.
  • Figueroa DA; Laboratory of Immunoncology, Fundación Ciencia & Vida, Santiago, Chile.
  • Roa E; Laboratory of Immunoncology, Fundación Ciencia & Vida, Santiago, Chile.
  • Quezada SA; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.
  • Lladser A; Laboratory of Immunoncology, Fundación Ciencia & Vida, Santiago, Chile. alladser@cienciavida.org.
Nat Commun ; 10(1): 4401, 2019 09 27.
Article em En | MEDLINE | ID: mdl-31562311
Tissue-resident memory CD8+ T (Trm) cells mediate potent local innate and adaptive immune responses and play a central role against solid tumors. However, whether Trm cells cross-talk with dendritic cells (DCs) to support anti-tumor immunity remains unclear. Here we show that antigen-specific activation of skin Trm cells leads to maturation and migration to draining lymph nodes of cross-presenting dermal DCs. Tumor rejection mediated by Trm cells triggers the spread of cytotoxic CD8+ T cell responses against tumor-derived neo- and self-antigens via dermal DCs. These responses suppress the growth of intradermal tumors and disseminated melanoma lacking the Trm cell-targeted epitope. Moreover, analysis of RNA sequencing data from human melanoma tumors reveals that enrichment of a Trm cell gene signature associates with DC activation and improved survival. This work unveils the ability of Trm cells to amplify the breath of cytotoxic CD8+ T cell responses through DCs, thereby strengthening anti-tumor immunity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Células Dendríticas / Linfócitos T CD8-Positivos / Memória Imunológica / Melanoma Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Células Dendríticas / Linfócitos T CD8-Positivos / Memória Imunológica / Melanoma Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido