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Adult Pilocytic Astrocytomas: A Brazilian Series.
Boschetti, Gabriela; Santos, Adrialdo Jose; Fermon, Kellen Paiva; de Freitas Honório, Gustavo Lopes; Batistella, Gabriel; Kusma, Solena Ziemer; Stávale, João Norberto; de Paiva Neto, Manoel Antonio; Fleury Malheiros, Suzana Maria.
Afiliação
  • Boschetti G; Department of Neurosurgery, Neuro-oncology Service, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil; School of Medicine Deparment, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil; Medical School Department, Faculdades Pequeno Príncipe, Curitiba, Paraná, Brazil. E
  • Santos AJ; Department of Neurosurgery, Neuro-oncology Service, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.
  • Fermon KP; Department of Neurosurgery, Neuro-oncology Service, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.
  • de Freitas Honório GL; Department of Neurosurgery, Neuro-oncology Service, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.
  • Batistella G; Department of Neurosurgery, Neuro-oncology Service, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.
  • Kusma SZ; School of Medicine Deparment, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil; Department of Public Health, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
  • Stávale JN; Department of Pathology, Neuropathology Service, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil; Department of Pathology, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil.
  • de Paiva Neto MA; Department of Neurosurgery, Neuro-oncology Service, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.
  • Fleury Malheiros SM; Department of Neurosurgery, Neuro-oncology Service, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil; Department of Oncology, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil.
World Neurosurg ; 133: e115-e120, 2020 Jan.
Article em En | MEDLINE | ID: mdl-31550545
OBJECTIVE: Pilocytic astrocytoma (PA) is rare in adults comprising 5.1% of the primary central nervous system tumors. The aim is to describe the first Brazilian series of adult patients with PA and compare its features with the available literature. METHODS: We retrospectively review all patients 18 years or older with PA from our institution's database from 1991 to 2018. We analyzed information regarding clinical presentation, location, imaging features, extent of resection, adjuvant treatments, and follow-up. RESULTS: Twenty-three patients with PA were analyzed: 60.9% male; median age 26 years. The most frequent symptoms were headache (34.8%) and seizure (26.1%). Temporal and parietal lobes were the most common locations, 21.7% each. All patients underwent a surgical procedure, gross total resection in 40.9%, subtotal resection in 22.7%, and biopsy in 27.3%. Adjuvant treatment with radiotherapy was performed in 2 patients. Only 4 patients had disease progression, 2 after gross total resection and 2 after subtotal resection. They were all alive and without evidence of new progression at the last follow-up (October 2018). Median overall survival was not reached after a median follow-up time of 88.9 months. CONCLUSIONS: This is the first Brazilian series regarding adults with PA, and our patients had a favorable outcome as reported in recent literature reviews. The tumor's prevalence reduces within older patients and supratentorial lesions are more frequent, especially on the temporal lobe. There was no significant relationship between location and progression, although according to the literature the extent of resection remains the most important prognostic factor.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Astrocitoma / Neoplasias Encefálicas Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: World Neurosurg Assunto da revista: NEUROCIRURGIA Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Astrocitoma / Neoplasias Encefálicas Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: World Neurosurg Assunto da revista: NEUROCIRURGIA Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos