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Frequency of Toxocara canis antibodies in Mexican paediatric patients with epilepsy.
Caballero-García, M D L; Simón-Salvador, J; Hernández-Aguilar, J C; Reyes-Lopez, A; Nogueda-Torres, B; Jiménez-Cardoso, E.
Afiliação
  • Caballero-García MDL; Laboratorio de Investigación en Parasitología, Hospital Infantil de México Federico Gómez, Dr. Márquez, 162, 06720 Mexico, Mexico.
  • Simón-Salvador J; Laboratorio de Investigación en Parasitología, Hospital Infantil de México Federico Gómez, Dr. Márquez, 162, 06720 Mexico, Mexico.
  • Hernández-Aguilar JC; Departamento de Neurología, Hospital Infantil de México Federico Gómez, Dr. Márquez 162, 06720 Mexico, Mexico.
  • Reyes-Lopez A; Medicina Basada en Evidencias, Hospital Infantil de México Federico Gómez, Dr. Márquez 162, 06720 Mexico, Mexico.
  • Nogueda-Torres B; Departamento de Parasitología, Escuela Nacional de Ciencias Biológica, Instituto Politécnico Nacional.
  • Jiménez-Cardoso E; Laboratorio de Investigación en Parasitología, Hospital Infantil de México Federico Gómez, Dr. Márquez, 162, 06720 Mexico, Mexico.
J Helminthol ; 94: e89, 2019 Sep 23.
Article em En | MEDLINE | ID: mdl-31544721
The relationship between epilepsy and the presence of visceral larva migrans caused by Toxocara canis in Mexican children remains uncertain; however, this relationship needs to be elucidated because these parasite larvae can invade the human central nervous system. Accordingly, this study aimed to determine the frequency and specificity of anti-T. canis antibodies in the sera of children with epilepsy to determine the relationship between this parasite and epilepsy. The sera samples of 214 children were examined: 111 children diagnosed with epilepsy and 103 clinically healthy children without neurological disorders. In the sera of each group, the presence and specificity of anti-T. canis and anti-Ascaris lumbricoides antibodies, as well as the cross-reactivity between them, were assessed using enzyme-linked immunosorbent assay and Western blotting analysis. Among the children with epilepsy, 25.2% exhibited seropositivity to T. canis. Cross-reactivity against the A. lumbricoides antigen was present in 46.8% of the children with epilepsy, whereas 11.7% of the children with epilepsy and anti-T. canis antibodies did not exhibit cross-reactivity against this antigen. The Western blotting analysis of the sera from the children with epilepsy demonstrated the presence of T. canis proteins, with molecular weights of 24, 35, 55, 70, 120 and 210 kDa, and A lumbricoides proteins with molecular weights of 70, 80 and 110 kDa. Our results revealed the presence of anti-T. canis antibodies in the children with epilepsy; furthermore, cross-reactivity tests with A. lumbricoides showed the importance of the presence of anti-T. canis antibodies in revealing the relationship between this parasite and epilepsy in children.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Anti-Helmínticos / Larva Migrans Visceral / Epilepsia Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Animals / Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: Mexico Idioma: En Revista: J Helminthol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Anti-Helmínticos / Larva Migrans Visceral / Epilepsia Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Animals / Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: Mexico Idioma: En Revista: J Helminthol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido