Your browser doesn't support javascript.
loading
Interleukin-6 Expression by Hypothalamic Microglia in Multiple Inflammatory Contexts: A Systematic Review.
Bobbo, Vanessa C D; Jara, Carlos P; Mendes, Natália F; Morari, Joseane; Velloso, Lício A; Araújo, Eliana P.
Afiliação
  • Bobbo VCD; Faculty of Nursing, University of Campinas, SP 13083-887, Brazil.
  • Jara CP; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, SP 13083-864, Brazil.
  • Mendes NF; Faculty of Nursing, University of Campinas, SP 13083-887, Brazil.
  • Morari J; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, SP 13083-864, Brazil.
  • Velloso LA; Faculty of Nursing, University of Campinas, SP 13083-887, Brazil.
  • Araújo EP; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, SP 13083-864, Brazil.
Biomed Res Int ; 2019: 1365210, 2019.
Article em En | MEDLINE | ID: mdl-31534953
Interleukin-6 (IL-6) is a unique cytokine that can play both pro- and anti-inflammatory roles depending on the anatomical site and conditions under which it has been induced. Specific neurons of the hypothalamus provide important signals to control food intake and energy expenditure. In individuals with obesity, a microglia-dependent inflammatory response damages the neural circuits responsible for maintaining whole-body energy homeostasis, resulting in a positive energy balance. However, little is known about the role of IL-6 in the regulation of hypothalamic microglia. In this systematic review, we asked what types of conditions and stimuli could modulate microglial IL-6 expression in murine model. We searched the PubMed and Web of Science databases and analyzed 13 articles that evaluated diverse contexts and study models focused on IL-6 expression and microglia activation, including the effects of stress, hypoxia, infection, neonatal overfeeding and nicotine exposure, lipopolysaccharide stimulus, hormones, exercise protocols, and aging. The results presented in this review emphasized the role of "injury-like" stimuli, under which IL-6 acts as a proinflammatory cytokine, concomitant with marked microglial activation, which drive hypothalamic neuroinflammation. Emerging evidence indicates an important correlation of basal IL-6 levels and microglial function with the maintenance of hypothalamic homeostasis. Advances in our understanding of these different contexts will lead to the development of more specific pharmacological approaches for the management of acute and chronic conditions, like obesity and metabolic diseases, without disturbing the homeostatic functions of IL-6 and microglia in the hypothalamus.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Interleucina-6 / Microglia / Hipotálamo / Doenças Metabólicas / Obesidade Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Animals / Humans Idioma: En Revista: Biomed Res Int Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Interleucina-6 / Microglia / Hipotálamo / Doenças Metabólicas / Obesidade Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Animals / Humans Idioma: En Revista: Biomed Res Int Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos