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Evaluation of the dopaminergic system with positron-emission tomography in alcohol abuse: A systematic review.
Alexandre, Maria Cecilia Manenti; Colonetti, Tamy; Bavaresco, Daniela V; Simon, Carla Sasso; Dondossola, Eduardo Ronconi; Uggioni, Maria Laura Rodrigues; Ferraz, Sarah Dagostin; Rico, Eduardo Pacheco; da Rosa, Maria Inês.
Afiliação
  • Alexandre MCM; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
  • Colonetti T; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
  • Bavaresco DV; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
  • Simon CS; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
  • Dondossola ER; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
  • Uggioni MLR; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
  • Ferraz SD; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
  • Rico EP; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
  • da Rosa MI; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil. Electronic address: mir@unesc.net.
Psychiatry Res ; 281: 112542, 2019 11.
Article em En | MEDLINE | ID: mdl-31521841
OBJECTIVE: Performed a systematic review to evaluated the dopaminergic system in alcohol abuse in a systematic review in humans. METHOD: A search of the electronic databases was proceeded, on MEDLINE, EMBASE, Cochrane Library, Insight and Gray literature (Google Scholar and the British Library) for studies published until August 2018. A search strategy was developed using the terms: "dopamine" and "ethanol" or ""alcohol"," and "positron-emission tomography" as text words and Medical Subject Headings (i.e., MeSH and EMTREE) and searched. RESULTS: We found 293 studies. After reading titles and abstracts 235 were considered irrelevant, as they did not meet the inclusion criteria. For the reading of the full text, 50 studies were analyzed. Of these 41 were excluded with reasons by study design, patient population, intervention and outcomes. Nine studies were included in our qualitative synthesis. Four studies have resulted in a reduction in availability only at the D2 receptor in different brain regions. Concerning the D3 receptor alone only one study reported this finding and four studies reported a decrease in both receptors. CONCLUSION: Changes in D2 receptors in several brain regions in human alcoholics were found in a systematic review.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tomografia por Emissão de Pósitrons / Alcoolismo / Neurônios Dopaminérgicos Tipo de estudo: Qualitative_research / Systematic_reviews Limite: Humans Idioma: En Revista: Psychiatry Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tomografia por Emissão de Pósitrons / Alcoolismo / Neurônios Dopaminérgicos Tipo de estudo: Qualitative_research / Systematic_reviews Limite: Humans Idioma: En Revista: Psychiatry Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda