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Hydrogel-embedded gold nanorods activated by plasmonic photothermy with potent antimicrobial activity.
Bermúdez-Jiménez, Carlos; Romney, Marc G; Roa-Flores, Samuel A; Martínez-Castañón, Gabriel; Bach, Horacio.
Afiliação
  • Bermúdez-Jiménez C; Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, BC, Canada; Laboratorio de Nanobiomateriales, Facultad de Estomatología, Universidad Autónoma de San Luis Potosí, Mexico.
  • Romney MG; Division of Medical Microbiology, St. Paul's Hospital, Providence Health Care, Vancouver, BC, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Roa-Flores SA; Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, BC, Canada; Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Nuevo León, Mexico.
  • Martínez-Castañón G; Laboratorio de Nanobiomateriales, Facultad de Estomatología, Universidad Autónoma de San Luis Potosí, Mexico.
  • Bach H; Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, BC, Canada. Electronic address: hbach@mail.ubc.ca.
Nanomedicine ; 22: 102093, 2019 11.
Article em En | MEDLINE | ID: mdl-31521833
Plasmonic photothermal therapy (PPTT) has been used as an alternative to chemotherapy for the elimination of resistant microorganisms; however, its in situ evaluation has not been well studied. In the present study, we assessed the antimicrobial activity of a chitosan-based hydrogel embedded with gold nanorods (Ch/AuNRs) using a low power infrared diode laser. The antibacterial activity was measured in both Gram-positive and -negative strains, including clinical isolates of multidrug-resistant pathogens. The cytotoxic effect, cellular proliferation, and the expression of the pro-inflammatory (IL-6 and TNF-α) and anti-inflammatory (IL-10) cytokines were quantified in a murine model of macrophages. Results showed a potent antimicrobial activity of the Ch/AuNRs with MICs ≤4 µg/mL, very low cytotoxicity with cell viability above 80%, and the macrophage proliferation was not affected for a period of 48 h. These results suggest that our Ch/AuNR-embedded hydrogel could be an option to locally control chronic nosocomial infections using PPTT.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fototerapia / Hidrogéis / Nanotubos / Ouro / Hipertermia Induzida / Anti-Infecciosos Limite: Animals Idioma: En Revista: Nanomedicine Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fototerapia / Hidrogéis / Nanotubos / Ouro / Hipertermia Induzida / Anti-Infecciosos Limite: Animals Idioma: En Revista: Nanomedicine Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos