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Advances in ophthalmic preparation: the role of drug nanocrystals and lipid-based nanosystems.
Peters, Maria Christina Camasmie; Santos Neto, Edson Dos; Monteiro, Lis Marie; Yukuyama, Megumi Nishitani; Machado, Marcella Gabrielle Mendes; de Oliveira, Isabela Fernandes; Zanin, Maria Helena Ambrosio; Löbenberg, Raimar; Bou-Chacra, Nádia.
Afiliação
  • Peters MCC; Faculty of Pharmaceutical Sciences, Department of Pharmacy, University of Sao Paulo, São Paulo, Brazil.
  • Santos Neto ED; Ophthalmology Division, Clinical Hospital of the Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
  • Monteiro LM; Faculty of Pharmaceutical Sciences, Department of Pharmacy, University of Sao Paulo, São Paulo, Brazil.
  • Yukuyama MN; Faculty of Pharmaceutical Sciences, Department of Pharmacy, University of Sao Paulo, São Paulo, Brazil.
  • Machado MGM; School of Pharmaceutical Sciences, São Paulo State University (UNESP), São Paulo, Brazil.
  • de Oliveira IF; Faculty of Pharmaceutical Sciences, Department of Pharmacy, University of Sao Paulo, São Paulo, Brazil.
  • Zanin MHA; Institute for Technological Research (IPT), São Paulo, Brazil.
  • Löbenberg R; Division of Pharmaceutical Sciences, Faculty of Pharmacy & Pharmaceutical Sciences, Katz Group-Rexall Centre for Pharmacy & Health Research, University of Alberta, Edmonton, Canada.
  • Bou-Chacra N; Faculty of Pharmaceutical Sciences, Department of Pharmacy, University of Sao Paulo, São Paulo, Brazil.
J Drug Target ; 28(3): 259-270, 2020 03.
Article em En | MEDLINE | ID: mdl-31491352
Nanocrystals and lipid-based nanosystems have the potential to play a crucial role in a significant shift in the treatment of ophthalmic diseases. These drug delivery systems allow overcoming the barriers imposed by anatomy and physiology of the organ of vision. This review aims to present new perspectives for these innovative preparations, emphasising the applications of the nanocrystal and lipid-based nanosystem while outlining their advantages and the drawbacks. The in vivo performance of the lipid-based nanosystems was highlighted. Lipid-based nanosystems and nanocrystals showed a prolonged effect, improved ocular bioavailability, upper therapeutic efficacy, higher permeation, prolonged residence time, and sustained drug release, compared to the current applications. Well-established and innovative developments updates of these systems are highlighted herein.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Oftalmopatias / Nanopartículas Limite: Animals / Humans Idioma: En Revista: J Drug Target Assunto da revista: FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Oftalmopatias / Nanopartículas Limite: Animals / Humans Idioma: En Revista: J Drug Target Assunto da revista: FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido