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High prevalence of human papillomavirus infection in HIV-infected women living in French Antilles and French Guiana.
Abel, Sylvie; Najioullah, Fatiha; Voluménie, Jean-Luc; Accrombessi, Laetitia; Carles, Gabriel; Catherine, Dominique; Chiappetta, Déborah; Clavel, Cyril; Codjo-Sodokine, Akua; El Guedj, Myriam; Jean-Marie, Janick; Molinié, Vincent; Pierre-François, Sandrine; Stegmann-Planchard, Sofia; Vantilcke, Vincent; Vaz, Tania; Nacher, Mathieu; Cabié, André; Césaire, Raymond.
Afiliação
  • Abel S; Infectious Diseases Department, CHU de Martinique, Fort-de-France, France.
  • Najioullah F; Université des Antilles, Fort-de-France, France.
  • Voluménie JL; Université des Antilles, Fort-de-France, France.
  • Accrombessi L; Virology Laboratory, CHU de Martinique, Fort-de-France, France.
  • Carles G; Gynecology Unit, CHU de Martinique, Fort-de-France, France.
  • Catherine D; Obstetrics and Gynecology Unit, Centre Hospitalier "Andrée Rosemon", Cayenne, France.
  • Chiappetta D; Obstetrics and Gynecology Unit, Centre Hospitalier de l'Ouest Guyanais Franck Joly, Saint-Laurent-du-Maroni, France.
  • Clavel C; Pathology Department, CHU de Martinique, Fort-de-France, France.
  • Codjo-Sodokine A; Inserm CIC1424, CHU de Martinique, Fort-de-France, France.
  • El Guedj M; Infectious Diseases Unit, Centre Hospitalier Louis Constant Fleming, Saint-Martin, France.
  • Jean-Marie J; Gynecology Unit, Centre Hospitalier Louis Constant Fleming, Saint-Martin, France.
  • Molinié V; Day Hospital Unit, Centre Hospitalier « Andrée Rosemon ¼, Cayenne, France.
  • Pierre-François S; Inserm CIC1424, CHU de Martinique, Fort-de-France, France.
  • Stegmann-Planchard S; Pathology Department, CHU de Martinique, Fort-de-France, France.
  • Vantilcke V; Infectious Diseases Department, CHU de Martinique, Fort-de-France, France.
  • Vaz T; Infectious Diseases Unit, Centre Hospitalier Louis Constant Fleming, Saint-Martin, France.
  • Nacher M; Infectious Diseases Unit, Centre Hospitalier de l'Ouest Guyanais Franck Joly, Saint-Laurent-du-Maroni, France.
  • Cabié A; Day Hospital Unit, Centre Hospitalier « Andrée Rosemon ¼, Cayenne, France.
  • Césaire R; Inserm CIC1424, Centre Hospitalier « Andrée Rosemon ¼, Cayenne, France.
PLoS One ; 14(9): e0221334, 2019.
Article em En | MEDLINE | ID: mdl-31483832
An association between HIV infection and cervical cancer, a major public health issue worldwide, has been reported. The aim of this study was to estimate the prevalence of human papillomavirus (HPV) infection and the distribution of HPV genotypes in HIV-infected women living in French Antilles and Guiana and to determine HIV-related characteristics associated with HPV infection. This cross-sectional study included 439 HIV-infected women who were followed between January 2011 and May 2014. Variables related to HIV infections were collected, and cervical samples were analysed to determine HPV genotypes. The median age of the population was 46 years. Estimated prevalence of HPV and high-risk (HR)-HPV infection were 50.1% IC95 [45.4-54.7] and 42% IC95 [37.3-46.6], respectively. HR-HPV 16, 52, 53 or intermediate risk-HPV-68 were found in 25% to 30% of the HPV-infected patients. Gynaecological screening revealed abnormal cervical smear in 24% and 42% of HR-HPV-negative and HPV-positive women, respectively (p = 0.003). Approximately 90% of women were on antiretroviral therapy (ART). Demographic characteristics associated with a higher prevalence of HPV infection included alcohol consumption. Regarding HIV-related characteristics, current therapy on ART, its duration, and undetectable plasma concentrations of RNA-HIV1 were associated with a lower risk of HPV infection. Infection rate with HR-HPV was higher than what is commonly reported in HIV-negative women worldwide and was more likely in women with incomplete HIV suppression. These results highlight the need for supporting adherence to ART, cervical cytology, HPV testing and HPV vaccination.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Infecções por Papillomavirus Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: America do sul / Caribe / Caribe ingles / Guadalupe / Guyana / Guyana francesa Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: França País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Infecções por Papillomavirus Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: America do sul / Caribe / Caribe ingles / Guadalupe / Guyana / Guyana francesa Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: França País de publicação: Estados Unidos