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Differences in omentin-1 levels in term newborns according to birth weight.
Hernández-Rodríguez, Citlalli E; Estrada-Zúñiga, Cynthia M; De la O-Cavazos, Manuel E; García-Rodríguez, Fernando; Rodríguez-Balderrama, Isaías; Zapata-Castilleja, Carlos A; Treviño-Garza, Consuelo.
Afiliação
  • Hernández-Rodríguez CE; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. Jose E. Gonzalez", Department of Pediatrics, Monterrey, Mexico.
  • Estrada-Zúñiga CM; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. Jose E. Gonzalez", Department of Pediatrics, Monterrey, Mexico.
  • De la O-Cavazos ME; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. Jose E. Gonzalez", Department of Pediatrics, Monterrey, Mexico.
  • García-Rodríguez F; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. Jose E. Gonzalez", Department of Pediatrics, Monterrey, Mexico.
  • Rodríguez-Balderrama I; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. Jose E. Gonzalez", Department of Pediatrics, Monterrey, Mexico.
  • Zapata-Castilleja CA; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. Jose E. Gonzalez", Department of Pediatrics, Monterrey, Mexico.
  • Treviño-Garza C; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. Jose E. Gonzalez", Department of Pediatrics, Monterrey, Mexico. Electronic address: cotrevin@hotmail.com.
Early Hum Dev ; 139: 104842, 2019 12.
Article em En | MEDLINE | ID: mdl-31476543
BACKGROUND: Adipokines are produced by adipose tissue and are involved in metabolic processes. Omentin-1 is an adipokine that has been shown in vitro to possibly be involved in insulin sensitivity modulation. The prenatal stage is a crucial period for development of metabolic diseases in the long term, therefore, small (SGA) and large (LGA) for gestational age newborns have an increased risk of type 2 diabetes and metabolic syndrome later in life. AIMS: To evaluate the differences in omentin-1 concentrations in umbilical cord blood from healthy term newborns according to birth weight and explore the association between omentin-1 and anthropometry, glucose, insulin and insulin sensitivity. STUDY DESIGN: This was a secondary analysis of stored umbilical cord blood of term newborns. SUBJECTS: Newborns classified according to birth weight as SGA (n = 30), adequate for gestational age (AGA) (n = 12) and LGA (n = 34). OUTCOME MEASURES: An analysis of omentin-1, glucose and insulin were performed. RESULTS: Differences were found in serum omentin-1 levels (ng/mL) between SGA 328.17 ±â€¯108.04, AGA 253.05 ±â€¯98.25 and LGA 250.91 ±â€¯100.48 (p = 0.009). In the linear regression analysis, the independent variables HOMA-IR, QUICK-I and FGIR were predictors of serum omentin-1 levels (r = 0.175, p = 0.003). CONCLUSIONS: Omentin-1 cord blood levels have a differentiated behavior according to weight for gestational age with LGA newborns having lower levels and SGA newborns higher levels. HOMA-IR, QUICK-I and FGIR weakly predicted omentin-1 in cord blood, suggesting that omentin-1 possibly has an implication in insulin sensitivity since birth.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peso ao Nascer / Recém-Nascido Pequeno para a Idade Gestacional / Citocinas / Lectinas Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male / Newborn Idioma: En Revista: Early Hum Dev Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Irlanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peso ao Nascer / Recém-Nascido Pequeno para a Idade Gestacional / Citocinas / Lectinas Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male / Newborn Idioma: En Revista: Early Hum Dev Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Irlanda