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Association between MICA rs2596542 Polymorphism with the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients.
Marangon, Camila Guerra; de Bitencorte, Jóice Teixeira; Michita, Rafael Tomoya; Lunge, Vagner Ricardo; Dos Santos, Deivid Cruz; Álvares-da-Silva, Mário Reis; Simon, Daniel.
Afiliação
  • Marangon CG; Human Molecular Genetics Laboratory, Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.
  • de Bitencorte JT; Human Molecular Genetics Laboratory, Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.
  • Michita RT; Human Molecular Genetics Laboratory, Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.
  • Lunge VR; Human Molecular Genetics Laboratory, Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil.
  • Dos Santos DC; Serviço de Gastroenterologia, Departamento de Medicina Interna, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
  • Álvares-da-Silva MR; Serviço de Gastroenterologia, Departamento de Medicina Interna, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
  • Simon D; Human Molecular Genetics Laboratory, Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil. daniel.simon@ulbra.br.
Pathol Oncol Res ; 26(3): 1519-1525, 2020 Jul.
Article em En | MEDLINE | ID: mdl-31471884
In this study we investigated the impact of rs2596542A/G single nucleotide polymorphism (SNP) in the major histocompatibility complex class I chain-related sequence A (MICA) gene on HCV-induced hepatocellular carcinoma (HCC) susceptibility in a Brazilian population. In total, 252 HCV-infected patients (98 with HCV-induced HCC and 154 non-malignant HCV-induced liver cirrhosis) were enrolled and 98 healthy control subjects (negative anti-HCV). The MICA rs2596542 SNP genotypes were determined by real-time PCR assay. No differences in MICA genotype frequencies between HCV-induced cirrhosis patients and controls were observed. However, genotype frequencies of rs2596542A/G SNP were statistically different between HCV-induced HCC patients and controls (p = 0.048), and also between HCC and HCV-induced cirrhosis patients (p = 0.039). The highest frequency of the rs2596542AA genotype was observed in HCC patients (31.6%) when compared with HCV-induced cirrhosis patients (18.8%) and healthy controls (19.4%). Also, rs2596542AA genotype carriers have an increased risk for HCC when compared to HCV-induced cirrhosis status [odds ratio (OR) = 1.99; 95% confidence interval (CI) = 1.06-3.74, p = 0.020)] and healthy individuals (OR = 1.92, 95% CI = 1.00-3.70, p = 0.049). Taken together our study suggest that MICA rs2596542 SNP impacts HCV-induced HCC susceptibility suggesting that genetic variants in MICA are of clinical relevance to hepatocarcinogenesis by impacting host immune response in chronic HCV infection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos de Histocompatibilidade Classe I / Carcinoma Hepatocelular / Hepatite C Crônica / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Pathol Oncol Res Assunto da revista: NEOPLASIAS / PATOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos de Histocompatibilidade Classe I / Carcinoma Hepatocelular / Hepatite C Crônica / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Pathol Oncol Res Assunto da revista: NEOPLASIAS / PATOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça