Your browser doesn't support javascript.
loading
The performance of M and XL probes of FibroScan for the diagnosis of steatosis and fibrosis on a Brazilian nonalcoholic fatty liver disease cohort.
Cardoso, Ana Carolina; Cravo, Claudia; Calçado, Fernanda Luiza; Rezende, Guilherme; Campos, Carlos Frederico F; Neto, João Marcello A; Luz, Rodrigo P; Soares, Jorge André S; Moraes-Coelho, Henrique Sergio; Leite, Nathalie C; Perez, Renata M; Villela-Nogueira, Cristiane A.
Afiliação
  • Cardoso AC; Hepatology Unit, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro.
  • Cravo C; Hepatology Unit, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro.
  • Calçado FL; Hepatology Unit, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro.
  • Rezende G; Hepatology Unit, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro.
  • Campos CFF; Anatomopathology Department, Rede D'Or São Luiz.
  • Neto JMA; Hepatology Unit, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro.
  • Luz RP; Hepatology Unit, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro.
  • Soares JAS; Hepatology Unit, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro.
  • Moraes-Coelho HS; Hepatology Unit, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro.
  • Leite NC; Hepatology Unit, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro.
  • Perez RM; Hepatology Unit, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro.
  • Villela-Nogueira CA; Gastroenterology Department, University of the State of Rio de Janeiro.
Eur J Gastroenterol Hepatol ; 32(2): 231-238, 2020 02.
Article em En | MEDLINE | ID: mdl-31464788
OBJECTIVES: Recently, controlled attenuation parameter (CAP) was incorporated for XL probe. However, its performance through M and XL probes has been scarcely evaluated in nonalcoholic fatty liver disease (NAFLD). The performance of probes regarding transient elastography by Fibroscan is still under debate. AIM: Compare the performance of CAP and transient elastography in NAFLD patients obtained through XL with M probes using histological analysis as gold standard. METHODS: NAFLD patients underwent liver biopsy and FibroScan/CAP with M and XL probes the same day. C-statistic evaluated CAP performance in the identification of moderate/severe (≥33%) and severe (≥66%) steatosis by both probes and transient elastography performance for identification of significant fibrosis (≥F2). RESULTS: Eighty-one patients (74% female; age 54.2 ± 9.9 years; BMI 32.8 ± 5.2/ BMI ≥ 25 92.6%; 96% metabolic syndrome; 60% diabetes mellitus) were included. Mean CAP with M and XL probes was 314 ± 39 and 325 ± 47 dB/m, respectively. The areas under receiver operating characteristic curves (AUROCs) of the M and XL probes for steatosis detection ≥33% were 0.75 (0.64-0.84) and 0.76 (0.65-0.84) (P = 0.95) and for steatosis ≥66% 0.83 (0.73-0.90) and 0.82 (0.71-0.89) (P = 0.73), respectively, with similar performances for both degrees of steatosis. Regarding transient elastography, AUROCs of M and XL probes for ≥F2 were 0.82 (0.71-0.93) and 0.80 (0.69-0.92) (P = 0.66). CONCLUSION: Performance of M and XL probes is similar for the diagnosis of moderate and severe steatosis and significant fibrosis even on a overweight population with NAFLD.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Técnicas de Imagem por Elasticidade / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Eur J Gastroenterol Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Técnicas de Imagem por Elasticidade / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Eur J Gastroenterol Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de publicação: Reino Unido