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INVESTIGATION OF ENTEROCOCCUS FAECALIS POPULATION IN PATIENTS WITH POLYP AND COLORECTAL CANCER IN COMPARISON OF HEALTHY INDIVIDUALS.
Geravand, Maryam; Fallah, Parviz; Yaghoobi, Mojtaba Hedayat; Soleimanifar, Fatemeh; Farid, Malihe; Zinatizadeh, Nazi; Yaslianifard, Somayeh.
Afiliação
  • Geravand M; Alborz University of Medical Sciences, School of Medicine, Student Research Committee, Karaj, Iran.
  • Fallah P; Alborz University of Medical Sciences, School of Paramedical Sciences, Department of Hematology, Karaj, Iran.
  • Yaghoobi MH; Alborz University of Medical Sciences, School of Medicine, Department of Infectious Disease, Karaj, Iran.
  • Soleimanifar F; Alborz University of Medical Sciences, Dietary Supplements and Probiotic Research Center, Karaj, Iran.
  • Farid M; Alborz University of Medical Sciences, Social Determinants of Health Research Center, Karaj, IR Iran.
  • Zinatizadeh N; Alborz University of Medical Sciences, Faculty of Medicine, Karaj, IR Iran.
  • Yaslianifard S; Alborz University of Medical Sciences, School of Medicine, Student Research Committee, Karaj, Iran.
Arq Gastroenterol ; 56(2): 141-145, 2019 Aug 13.
Article em En | MEDLINE | ID: mdl-31460576
BACKGROUND: Colorectal cancer is one of the most commonly diagnosed cancers around the world. One of the factors involved in the development of colorectal cancer is the changes in the normal flora of the intestine. OBJECTIVE: In this study, the mean copy number of Enterococcus faecalis in people with polyps and people with colorectal cancer has been evaluated in comparison with healthy controls. METHODS: In this study, 25 patients with colorectal cancer and 28 patients with intestinal polyps were selected and stool specimens were taken. In addition, 24 healthy individuals were selected as control group. Extraction of bacterial DNA from the stool sample were performed. The molecular methods of PCR for confirmation of standard strain and absolute Real Time PCR (qRT-PCR) method were used to evaluate the number of Enterococcus faecalis in the studied groups. RESULTS: The results of this study indicate that the mean copy number of Enterococcus faecalis in patients with colorectal cancer was 11.2x109 per gram of stool, and in patients with polyps was 9.4x108 per gram of stool. In healthy people, this number was 9x108 per gram of stool. There was a significant difference between the implicit copy numbers in the three groups. (P<0.05). CONCLUSION: Enterococcus faecalis in faecal flora of people with colorectal cancer was significantly higher than those with polyps and healthy people. This could potentially signify the ability of this bacterium to induce colorectal cancer. More studies are needed to prove this theory.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Pólipos do Colo / Enterococcus faecalis / Fezes Tipo de estudo: Observational_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arq Gastroenterol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Pólipos do Colo / Enterococcus faecalis / Fezes Tipo de estudo: Observational_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arq Gastroenterol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil