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Sinonasal inverted papilloma: rate of recurrence and malignant transformation in 44 operated patients.
Sbrana, Mariana Ferreira; Borges, Renata Ferraz Rafael; Pinna, Fábio de Rezende; Neto, Deusdedit Brandão; Voegels, Richard Louis.
Afiliação
  • Sbrana MF; Universidade de São Paulo (USP), Departamento de Otorrinolaringologia, São Paulo, SP, Brazil. Electronic address: mariana.sbrana@yahoo.com.br.
  • Borges RFR; Universidade de São Paulo (USP), Departamento de Otorrinolaringologia, São Paulo, SP, Brazil.
  • Pinna FR; Universidade de São Paulo (USP), Departamento de Otorrinolaringologia, São Paulo, SP, Brazil.
  • Neto DB; Universidade de São Paulo (USP), Departamento de Otorrinolaringologia, São Paulo, SP, Brazil.
  • Voegels RL; Universidade de São Paulo (USP), Departamento de Otorrinolaringologia, São Paulo, SP, Brazil.
Braz J Otorhinolaryngol ; 87(1): 80-84, 2021.
Article em En | MEDLINE | ID: mdl-31455578
INTRODUCTION: Although sinonasal inverted papillomas are benign lesions, they are locally aggressive and have a potential malignant transformation ranging from 5% to 15%, with a high recurrence rate. OBJECTIVE: The aim of this article is to describe the rate of recurrence and malignant transformation in patients with a diagnosis of inverted papilloma who underwent surgery in a tertiary hospital in São Paulo. METHODS: We performed a retrospective analysis of patients diagnosed with sinonasal papilloma who had undergone surgery in a tertiary hospital in São Paulo, between August 1998 and August 2017. A patient chart review was conducted to assess data of patients' demographics, tumors characteristics, follow-up appointments, recurrence and malignancy. Inverted papillomas were analyzed and classified under the Krouse staging system. RESULTS: A total of 69 surgeries were performed in patients with diagnosis of sinonasal papilloma. Inverted papilloma was the most prevalent subtype (49 cases ‒ 80.33%), followed by exophytic papilloma (6 cases ‒ 9.84%) and by oncocytic papilloma (6 cases - 9.84%). The recurrence rate was 34.09% for inverted papilloma (15/44) and the mean time of recurrence was 24.6 months. Malignant transformation occurred in 6 patients (13.64%). Three of these patients presented carcinoma in the first surgery and three patients developed carcinoma during the follow-up. CONCLUSION: The high recurrence rate and malignancy potential allow us to consider inverted papillomas as aggressive tumors. In a tertiary hospital in São Paulo the recurrence rate the mean time to recurrence is 24.6 months. The recurrence after 10 years implies was 34.09% and the need for long-term follow up. It is possible that the high recurrence rate and the high malignant transformation rate we found are due to the large number of tumors discovered at an advanced stage (most of them staged T3 and T4), secondary to poor access to health system, in developing countries.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias dos Seios Paranasais / Neoplasias Nasais / Papiloma Invertido Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Braz J Otorhinolaryngol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias dos Seios Paranasais / Neoplasias Nasais / Papiloma Invertido Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Braz J Otorhinolaryngol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Brasil