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Docosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis and related parameters in mice subjected to high-fat diet: A molecular approach.
Soto-Alarcón, Sandra A; Ortiz, Macarena; Orellana, Paula; Echeverría, Francisca; Bustamante, Andrés; Espinosa, Alejandra; Illesca, Paola; Gonzalez-Mañán, Daniel; Valenzuela, Rodrigo; Videla, Luis A.
Afiliação
  • Soto-Alarcón SA; Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.
  • Ortiz M; Nutrition and Dietetics School, Faculty of Health Sciences, Catholic University of Maule, Curicó, Chile.
  • Orellana P; Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.
  • Echeverría F; Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.
  • Bustamante A; Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.
  • Espinosa A; Department of Medical Technology, Faculty of Medicine, University of Chile, Santiago, Chile.
  • Illesca P; Biochemistry Department, Faculty of Biochemistry, University of Litoral, Santa Fe, Argentina.
  • Gonzalez-Mañán D; Núcleo de Química y Bioquímica, Facultad de Ciencias, Universidad Mayor, Chile.
  • Valenzuela R; Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.
  • Videla LA; Molecular and Clinical Pharmacology Program, Institute of Biomedical Science, Faculty of Medicine, University of Chile, Santiago, Chile.
Biofactors ; 45(6): 930-943, 2019 Nov.
Article em En | MEDLINE | ID: mdl-31454114
Attenuation of high-fat diet (HFD)-induced liver steatosis is accomplished by different nutritional interventions. Considering that the n-3 PUFA docosahexaenoic acid (DHA) modulates lipid metabolism and the antioxidant hydroxytyrosol (HT) diminishes oxidative stress underlying fatty liver, it is hypothesized that HFD-induced steatosis is suppressed by DHA and HT co-administration. Male C57BL/6J mice were fed a control diet (CD; 10% fat, 20% protein, 70% carbohydrates) or a HFD (60% fat, 20% protein, 20% carbohydrates) for 12 weeks, without and with supplementation of DHA (50 mg/kg/day), HT (5 mg/kg/day) or both. The combined DHA + HT protocol fully prevented liver steatosis and the concomitant pro-inflammatory state induced by HFD, with suppression of lipogenic and oxidative stress signaling, recovery of fatty acid oxidation capacity and enhancement in resolvin availability affording higher inflammation resolution capability. Abrogation of HFD-induced hepatic steatosis by DHA and HT co-administration represents a crucial therapeutic strategy eluding disease progression into stages lacking efficacious handling at present time.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Álcool Feniletílico / Ácidos Docosa-Hexaenoicos / Fígado Gorduroso / Inflamação Tipo de estudo: Etiology_studies / Guideline Limite: Animals / Humans Idioma: En Revista: Biofactors Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Chile País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Álcool Feniletílico / Ácidos Docosa-Hexaenoicos / Fígado Gorduroso / Inflamação Tipo de estudo: Etiology_studies / Guideline Limite: Animals / Humans Idioma: En Revista: Biofactors Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Chile País de publicação: Holanda