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Bioinformatics analysis of circulating miRNAs related to cancer following spinal cord injury.
Lopes, Elisangela C P; Paim, Layde R; Matos-Souza, José R; Calegari, Décio R; Gorla, José I; Cliquet, Alberto; Lima, Carmen S P; McDonald, John F; Nadruz, Wilson; Schreiber, Roberto.
Afiliação
  • Lopes ECP; Department of Internal Medicine, State University of Campinas Faculty of Medical Sciences, Campinas, SP, Brazil.
  • Paim LR; Department of Internal Medicine, State University of Campinas Faculty of Medical Sciences, Campinas, SP, Brazil.
  • Matos-Souza JR; Department of Internal Medicine, State University of Campinas Faculty of Medical Sciences, Campinas, SP, Brazil.
  • Calegari DR; School of Physical Education, University of Maringá, Maringá, PR, Brazil.
  • Gorla JI; School of Physical Education, State University of Campinas, Campinas, SP, Brazil.
  • Cliquet A; Department of Orthopedics, State University of Campinas Faculty of Medical Sciences, Campinas, SP, Brazil.
  • Lima CSP; Department of Electrical Engineering, University of São Paulo, São Carlos, SP, Brazil.
  • McDonald JF; Department of Internal Medicine, State University of Campinas Faculty of Medical Sciences, Campinas, SP, Brazil.
  • Nadruz W; School of Biology, Petit Institute of Bioengineering and BioSciences, Georgia Institute of Technology, Atlanta, GA, U.S.A.
  • Schreiber R; Department of Internal Medicine, State University of Campinas Faculty of Medical Sciences, Campinas, SP, Brazil.
Biosci Rep ; 39(9)2019 09 30.
Article em En | MEDLINE | ID: mdl-31444279
Patients with spinal cord injury (SCI) have an increased risk of developing esophageal, bladder and hematologic malignancies compared with the normal population. In the present study, we aimed to identify, through in silico analysis, miRNAs and their target genes related to the three most frequent types of cancer in individuals with SCI. In a previous study, we reported a pattern of expression of miRNAs in 17 sedentary SCI males compared with 22 healthy able-bodied males by TaqMan OpenArray. This list of miRNAs deregulated in SCI patients was uploaded to miRWALK2.0 to predict the target genes and pathways of selected miRNAs. We used Cytoscape software to construct the network displaying the miRNAs and their gene targets. Among the down-regulated miRNAs in SCI, 21, 19 and 20 miRNAs were potentially associated with hematological, bladder and esophageal cancer, respectively, and three target genes (TP53, CCND1 and KRAS) were common to all three types of cancer. The three up-regulated miRNAs were potentially targeted by 18, 15 and 10 genes associated with all three types of cancer. Our current bioinformatics analysis suggests the potential influence of several miRNAs on the development of cancer in SCI. In general, these data may provide novel information regarding potential molecular mechanisms involved in the development of cancer among individuals with SCI. Further studies aiming at understanding how miRNAs contribute to the development of the major cancers that affect patients after SCI may help elucidate the role of these molecules in the pathophysiology of the disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Biologia Computacional / MicroRNAs / Ácidos Nucleicos Livres Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Biosci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Biologia Computacional / MicroRNAs / Ácidos Nucleicos Livres Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Biosci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido