A high number of pfmdr1 gene copies in P. falciparum from Venezuela.
Parasitol Res
; 118(10): 3085-3089, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-31396714
Multidrug resistance in Plasmodium falciparum has been associated with gene amplification of pfmdr1. We studied the corresponding gene amplification in P. falciparum from blood samples of malaria patients in the Sifontes Municipality, Bolívar State, Venezuela, known as the highest region of incidence of malaria. Fifty-five P. falciparum DNA samples were extracted from different hosts and used for qPCR assessment of the copy number of pfmdr1. The assay detected four copies of the multidrug-resistant line P. falciparum Dd2 in comparison with the P. falciparum 3D7 that had only one copy. In the patients' samples, the copy number of pfmdr1 was a single copy in 80% and 20% left distributed in different copy numbers up to seven.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Proteínas de Protozoários
/
Malária Falciparum
/
Proteínas Associadas à Resistência a Múltiplos Medicamentos
Limite:
Humans
País/Região como assunto:
America do sul
/
Venezuela
Idioma:
En
Revista:
Parasitol Res
Assunto da revista:
PARASITOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Venezuela
País de publicação:
Alemanha