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ADA activity is decreased in lymphocytes from patients with advanced stage of lung cancer.
Zanini, Daniela; Manfredi, Leandro Henrique; Pelinson, Luana Paula; Pimentel, Victor Camera; Cardoso, Andréia Machado; Carmo Araújo Gonçalves, Viviane do; Santos, Cláudia Bertoncelli Dos; Gutierres, Jessié Martins; Morsch, Vera Maria; Leal, Daniela Bitencourt Rosa; Schetinger, Maria Rosa Chitolina.
Afiliação
  • Zanini D; Medical School, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil. daniela.zanini@uffs.edu.br.
  • Manfredi LH; Molecular biochemistry and biology, Federal University of Santa Maria, Santa Maria, 97105-900, Rio Grande do Sul, Brazil. daniela.zanini@uffs.edu.br.
  • Pelinson LP; Medical School, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil. leandrohm@gmail.com.
  • Pimentel VC; Molecular biochemistry and biology, Federal University of Santa Maria, Santa Maria, 97105-900, Rio Grande do Sul, Brazil.
  • Cardoso AM; Molecular biochemistry and biology, Federal University of Santa Maria, Santa Maria, 97105-900, Rio Grande do Sul, Brazil.
  • Carmo Araújo Gonçalves VD; Medical School, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil.
  • Santos CBD; Molecular biochemistry and biology, Federal University of Santa Maria, Santa Maria, 97105-900, Rio Grande do Sul, Brazil.
  • Gutierres JM; Molecular biochemistry and biology, Federal University of Santa Maria, Santa Maria, 97105-900, Rio Grande do Sul, Brazil.
  • Morsch VM; Molecular biochemistry and biology, Federal University of Santa Maria, Santa Maria, 97105-900, Rio Grande do Sul, Brazil.
  • Leal DBR; Molecular biochemistry and biology, Federal University of Santa Maria, Santa Maria, 97105-900, Rio Grande do Sul, Brazil.
  • Schetinger MRC; Molecular biochemistry and biology, Federal University of Santa Maria, Santa Maria, 97105-900, Rio Grande do Sul, Brazil.
Med Oncol ; 36(9): 78, 2019 Aug 02.
Article em En | MEDLINE | ID: mdl-31375946
Cigarette smoking is directly associated with lung cancer. Non-small cell lung carcinoma (NSCLC) represents approximately 80% from all types of lung cancer. This latter is hard to diagnose and to treat due to the lack of symptoms in early stages of the disease. The aim of this study was to evaluate ADA activity and the expression of P2X7, A1, and A2A receptors and in lymphocytes. In addition, the profile of pro-inflammatory and anti-inflammatory cytokines serum levels of patients with lung cancer in advanced stage was evaluated. Patients (n = 13) previously treated for lung cancer at stage IV (UICC) with chemotherapy had their blood collected. Cancer patients showed a decrease in ADA activity and an increase in A1 receptor expression in lymphocytes when compared to the control group. Moreover, patients exhibited an increase in IL-6 and TNF-α, while IL-17 and INF-ϒ serum levels were lower in patients with lung cancer. The decreased ADA activity and the increase in A1 receptor expression may contribute to adenosine pro-tumor effects by increasing IL-6 and TNF-α and decreasing IL-17 and INF-γ serum levels. Our data show an indirect evidence that purinergic signaling may have a role in promoting a profile of cytokines levels that favors tumor progression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos / Adenosina Desaminase / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Med Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos / Adenosina Desaminase / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Med Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos