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In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma.
Ye, Qing; Li, Jing; Wang, Xiaoyan; Zhang, Xianzeng; Lin, Jun; Huo, Yuting; Sun, Zhengzhen; Xie, Shusen; Huang, Zheng.
Afiliação
  • Ye Q; Fujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, China.
  • Li J; Fujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, China. Electronic address: 417357225@qq.com.
  • Wang X; Fujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, China.
  • Zhang X; Fujian Normal University, OptoElectronic Science and Technology for Medicine, MOE Key Laboratory, Fujian, China.
  • Lin J; Fujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, China.
  • Huo Y; Fujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, China.
  • Sun Z; Fujian Medical University, Fujian Provincial Hospital and Provincial Clinical College, Department of Otolaryngology, Fujian, China.
  • Xie S; Fujian Normal University, OptoElectronic Science and Technology for Medicine, MOE Key Laboratory, Fujian, China.
  • Huang Z; Fujian Normal University, OptoElectronic Science and Technology for Medicine, MOE Key Laboratory, Fujian, China.
Braz J Otorhinolaryngol ; 86(5): 617-625, 2020.
Article em En | MEDLINE | ID: mdl-31375471
INTRODUCTION: Nasopharyngeal carcinoma, an epithelial-derived malignant tumor which because of its anatomical location and atypical early symptoms, when diagnosed invasion and metastasis often have occurred. This requires a better understanding of the development mechanism, identifying diagnostic markers, and developing new treatment strategies. OBJECTIVE: To study the relationship of LMP1 and Cripto-1 in nasopharyngeal carcinoma. METHODS: The expression of LMP1 and Cripto-1 in specimens obtained from nasopharyngeal carcinoma patients (n=42) and nasopharyngitis patients (n=22) were examined. The expression of LMP1 and Cripto-1 in LMP1-negative and LMP1-positive (CNE1-LMP1) cells were also examined. RESULTS: The expression of LMP1 and Cripto-1 was significantly higher in nasopharyngeal carcinoma than in nasopharyngitis (p<0.05). Their expression in nasopharyngeal carcinoma with metastasis were significantly higher than that without metastasis (p<0.05), which was correlated with TNM staging (p<0.05). High Cripto-1 expression and high proliferation rate were seen in CNE1-LMP1 cells. CONCLUSIONS: The expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma is positively related. Their co-expression might contribute to the proliferation and metastasis of nasopharyngeal carcinoma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Nasofaríngeas / Carcinoma Nasofaríngeo Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Braz J Otorhinolaryngol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Nasofaríngeas / Carcinoma Nasofaríngeo Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Braz J Otorhinolaryngol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Brasil