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Effect of Simulated Geomagnetic Activity on Myocardial Ischemia/Reperfusion Injury in Rats.
Wu, Hui; Chang, Weiyu; Deng, Yanglin; Chen, Xinli; Ding, Yongli; Li, Xuesong; Dong, Liang.
Afiliação
  • Wu H; The First Affiliated Hospital of Kunming Medical University Department of Pharmacy Kunming Yunnan People's Republic of China Department of Pharmacy, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.
  • Chang W; The First Affiliated Hospital of Kunming Medical University Department of Pharmacy Kunming Yunnan People's Republic of China Department of Pharmacy, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.
  • Deng Y; The First Affiliated Hospital of Kunming Medical University Department of Pharmacy Kunming Yunnan People's Republic of China Department of Pharmacy, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.
  • Chen X; The First Affiliated Hospital of Kunming Medical University Department of Pharmacy Kunming Yunnan People's Republic of China Department of Pharmacy, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.
  • Ding Y; The First Affiliated Hospital of Kunming Medical University Department of Pharmacy Kunming Yunnan People's Republic of China Department of Pharmacy, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.
  • Li X; The First Affiliated Hospital of Kunming Medical University Department of Pharmacy Kunming Yunnan People's Republic of China Department of Pharmacy, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.
  • Dong L; Chinese Academy of Sciences Yunnan Observatories Kunming Yunnan People's Republic of China Yunnan Observatories, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
Braz J Cardiovasc Surg ; 34(6): 674-679, 2019 12 01.
Article em En | MEDLINE | ID: mdl-31364342
OBJECTIVE: To study the response of myocardial ischemia/reperfusion injury (MI/RI) in rats to simulated geomagnetic activity. METHODS: In a simulated strong geomagnetic outbreak, the MI/RI rat models were radiated, and their area of myocardial infarction, hemodynamic parameters, creatine kinase (CK), lactate dehydrogenase (LDH), melatonin, and troponin I values were measured after a 24-hour intervention. RESULTS: Our analysis indicates that the concentrations of troponin I in the geomagnetic shielding+operation group were lower than in the radiation+operation group (P<0.05), the concentrations of melatonin in the shielding+operation group and normal+operation group were higher than in the radiation + operation group (P<0.01), and the concentrations of CK in the shielding + operation group were lower than in the radiation + operation group and normal + operation group (P<0.05). Left ventricular developed pressure (LVDP) and ± dP/dtmax in the radiation+operation group were lower than in the shielding + operation group and normal+operation group (P<0.01). Left ventricular end-diastolic pressure (LEVDP) in the shielding + operation group was higher than in the normal + operation group (P<0.05). There was no significant difference in area of myocardial infarction and LDH between the shielding + operation group and the radiation + operation group. CONCLUSION: Our data suggest that geomagnetic activity is important in regulating myocardial reperfusion injury. The geomagnetic shielding has a protective effect on myocardial injury, and the geomagnetic radiation is a risk factor for aggravating the cardiovascular and cerebrovascular diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão Miocárdica / Campos Magnéticos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Braz J Cardiovasc Surg Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão Miocárdica / Campos Magnéticos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Braz J Cardiovasc Surg Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de publicação: Brasil