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Lactated Ringer's Versus 4% Albumin on Lactated Ringer's in Early Sepsis Therapy in Cancer Patients: A Pilot Single-Center Randomized Trial.
Park, Clarice Hyesuk Lee; de Almeida, Juliano Pinheiro; de Oliveira, Gisele Queiroz; Rizk, Stéphanie Itala; Fukushima, Julia Tizue; Nakamura, Rosana Ely; Mourão, Matheus Moraes; Galas, Filomena Regina Barbosa Gomes; Abdala, Edson; Pinheiro Freire, Maristela; Kalil Filho, Roberto; Costa Auler, Jose Otavio; Nardelli, Pasquale; Martin, Greg S; Landoni, Giovanni; Hajjar, Ludhmila Abrahao.
Afiliação
  • Park CHL; Department of Intensive Care, Cancer Institute, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • de Almeida JP; Department of Intensive Care, Cancer Institute, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • de Oliveira GQ; Department of Intensive Care, Cancer Institute, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Rizk SI; Department of Intensive Care, Cancer Institute, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Fukushima JT; Department of Intensive Care, Cancer Institute, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Nakamura RE; Department of Intensive Care, Cancer Institute, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Mourão MM; Department of Intensive Care, Cancer Institute, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Galas FRBG; Division of Anesthesia, Heart Institute, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Abdala E; Department of Infectious Diseases, Cancer Institute, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Pinheiro Freire M; Department of Infectious Diseases, Cancer Institute, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Kalil Filho R; Department of Cardiopneumology, Heart Institute, Faculty of Medicine, University of Sao Paulo, Brazil.
  • Costa Auler JO; Department of Cardiology, Hospital Siriolibanes, Sao Paulo, Brazil.
  • Nardelli P; Division of Anesthesia, Heart Institute, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Martin GS; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Landoni G; Division of Pulmonary, Allergy and Critical Care, Emory University, Atlanta, GA.
  • Hajjar LA; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Crit Care Med ; 47(10): e798-e805, 2019 10.
Article em En | MEDLINE | ID: mdl-31356475
OBJECTIVE: To investigate the effects of the administration of 4% albumin on lactated Ringer's, when compared with lactated Ringer's alone, in the early phase of sepsis in cancer patients. DESIGN: Single-center, randomized, double-blind, controlled-parallel trial. SETTING: A tertiary care university cancer hospital. PATIENTS: Cancer patients with severe sepsis or septic shock. INTERVENTIONS: Between October 2014 and December 2016, patients were randomly assigned to receive either bolus of albumin in a lactated Ringer's solution or lactated Ringer's solution alone during the first 6 hours of fluid resuscitation after intensive care medicine (ICU) admission. Primary outcome was defined as death from any cause at 7 days. Secondary outcomes were defined as death from any cause within 28 days, change in Sequence Organ Failure Assessment scores from baseline to day 7, days alive and free of mechanical ventilation, days alive and free of vasopressor, renal replacement therapy during ICU stay, and length of ICU and hospital stay. MEASUREMENTS AND MAIN RESULTS: A total of 360 patients were enrolled in the trial. At 7 days, 46 of 180 patients (26%) died in the albumin group and 40 of 180 (22%) died in the lactated Ringer's group (p = 0.5). At 28 days, 96 of 180 patients (53%) died in the albumin group and 83 of 180 (46%) died in the lactated Ringer's group (p = 0.2). No significant differences in secondary outcomes were observed. CONCLUSIONS: Adding albumin to early standard resuscitation with lactated Ringer's in cancer patients with sepsis did not improve 7-day survival.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sepse / Albuminas / Hidratação / Lactato de Ringer Tipo de estudo: Clinical_trials Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Crit Care Med Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sepse / Albuminas / Hidratação / Lactato de Ringer Tipo de estudo: Clinical_trials Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Crit Care Med Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos