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Maqui berry (Aristotelia chilensis) extract improves memory and decreases oxidative stress in male rat brain exposed to ozone.
Bribiesca-Cruz, Iván; Moreno, Diego A; García-Viguera, Cristina; Gallardo, Juan Manuel; Segura-Uribe, Julia J; Pinto-Almazán, Rodolfo; Guerra-Araiza, Christian.
Afiliação
  • Bribiesca-Cruz I; Unidad de Investigación Médica en Farmacología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Moreno DA; CEBAS-CSIC, Food Science and Technology Department, Phytochemistry and Healthy Foods Lab, Campus Universitario de Espinardo, Murcia, Spain.
  • García-Viguera C; CEBAS-CSIC, Food Science and Technology Department, Phytochemistry and Healthy Foods Lab, Campus Universitario de Espinardo, Murcia, Spain.
  • Gallardo JM; Unidad de Investigación Médica en Enfermedades Nefrológicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Segura-Uribe JJ; Unidad de Investigación Médica en Enfermedades Neurológicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Pinto-Almazán R; Unidad de Investigación del Hospital Regional de Alta Especialidad de Ixtapaluca, Municipio de Ixtapaluca, Mexico.
  • Guerra-Araiza C; Unidad de Investigación Médica en Farmacología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Nutr Neurosci ; 24(6): 477-489, 2021 Jun.
Article em En | MEDLINE | ID: mdl-31354109
Introduction: Prolonged ozone exposure can produce a state of oxidative stress, which in turn causes alterations in the dynamics of the brain and affects memory and learning. Moreover, different investigations have shown that high flavonoid content berries show a great antioxidant activity. The relationship between the protective effect of the maqui berry extract and its antioxidant properties in the brain has not been studied in depth. Objectives: The present study evaluated whether the protection exerted by the aqueous extract of maqui berry in brain regions associated with cognitive performance is due to its antioxidant capacity. Methods: Sprague Dawley rats were exposed to 0.25 ppm ozone and administered with maqui berry extracts. At the end of the treatments, spatial learning and short- and long-term memory were evaluated, as well as oxidative stress markers. Results: The administration of 50 and 100 mg/kg of the aqueous extract of maqui berry was effective in preventing the cognitive deficit caused by chronic exposure to ozone. The antioxidant effect of the administration of maqui berry was analyzed in the prefrontal cortex, hippocampus, and amygdala. Oxidative stress markers levels decreased and the enzymatic activity of superoxide dismutase diminished in animals exposed to ozone treated with the 50 mg/kg dose of maqui berry. Discussion: These results show a relationship between protection at the cognitive level and a decrease in oxidative stress markers, which suggests that the prevention of cognitive damage is due to the antioxidant activity of the maqui berry.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ozônio / Encéfalo / Extratos Vegetais / Estresse Oxidativo / Memória / Antioxidantes Tipo de estudo: Qualitative_research Limite: Animals País/Região como assunto: America do sul / Chile Idioma: En Revista: Nutr Neurosci Assunto da revista: CIENCIAS DA NUTRICAO / NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ozônio / Encéfalo / Extratos Vegetais / Estresse Oxidativo / Memória / Antioxidantes Tipo de estudo: Qualitative_research Limite: Animals País/Região como assunto: America do sul / Chile Idioma: En Revista: Nutr Neurosci Assunto da revista: CIENCIAS DA NUTRICAO / NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido