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First three Escherichia coli isolates harbouring mcr-1 in Uruguay.
Papa-Ezdra, Romina; Grill Diaz, Fabio; Vieytes, Mariela; García-Fulgueiras, Virginia; Caiata, Leticia; Ávila, Pablo; Brasesco, María; Christophersen, Inés; Cordeiro, Nicolás F; Algorta, Gabriela; Galiana, Antonio; Vignoli, Rafael.
Afiliação
  • Papa-Ezdra R; Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina Universidad de la República, Montevideo, Uruguay.
  • Grill Diaz F; Unidad de Enfermedades Infecciosas, Hospital Maciel, ASSE, Montevideo, Uruguay.
  • Vieytes M; Servicio de Microbiología, Hospital Maciel, ASSE, Montevideo, Uruguay.
  • García-Fulgueiras V; Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina Universidad de la República, Montevideo, Uruguay.
  • Caiata L; Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina Universidad de la República, Montevideo, Uruguay.
  • Ávila P; Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina Universidad de la República, Montevideo, Uruguay.
  • Brasesco M; Servicio de Microbiología, Hospital Maciel, ASSE, Montevideo, Uruguay.
  • Christophersen I; Servicio de Microbiología, Hospital Maciel, ASSE, Montevideo, Uruguay.
  • Cordeiro NF; Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina Universidad de la República, Montevideo, Uruguay.
  • Algorta G; Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina Universidad de la República, Montevideo, Uruguay.
  • Galiana A; Servicio de Microbiología, Hospital Maciel, ASSE, Montevideo, Uruguay.
  • Vignoli R; Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina Universidad de la República, Montevideo, Uruguay. Electronic address: rvignoli@higiene.edu.uy.
J Glob Antimicrob Resist ; 20: 187-190, 2020 03.
Article em En | MEDLINE | ID: mdl-31336172
OBJECTIVE: This report described the first Escherichia coli (E. coli) isolates harbouring mcr-1 in Uruguay. METHODS: Three E. coli isolates were obtained from blood, urine and rectal swabs from different patients in two hospitals. Extended-spectrum ß-lactamases (ESBL), plasmid-encoded (pAmpC) ß-lactamases, plasmid-mediated quinolone resistance (PMQR) genes, class 1 integrons, and mcr-1, mcr-2 and mcr-3 were sought and characterised in three E. coli isolates. Transfer of resistance determinants was assessed by conjugation. Clonality was analysed by multilocus sequence typing. RESULTS: All isolates were categorised as being colistin-resistant and the mcr-1 gene was detected. Two isolates were also resistant to oxyimino cephalosporins: one on account of blaCMY-2 and the other due to blaCTX-M-15, the latter also harbouring transferable quinolone-resistance genes (aac(6')Ib-cr and qnrB). All mcr-1 genes were transferred by conjugation to recipient strains. The mcr-1-bearing isolates belonged to sequence types ST10, ST93 and ST5442. CONCLUSIONS: ST10 is considered as a high-risk clone worldwide. This type of mcr-1-harbouring clone is a major concern for human and animal health and must be under close surveillance. This study detected the presence of mcr-1 for the first time in Uruguay, albeit in an allodemic manner, associated with different antibiotic-resistance genes and from diverse clinical contexts. Considering that colistin is often the last therapeutic option available for multidrug-resistant Gram-negative bacilli infections, it is important to maximise precautions to avoid dissemination of isolates carrying mcr-1.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Escherichia coli / Farmacorresistência Bacteriana / Escherichia coli / Infecções por Escherichia coli Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged80 / Female / Humans / Male País/Região como assunto: America do sul / Uruguay Idioma: En Revista: J Glob Antimicrob Resist Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Uruguai País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Escherichia coli / Farmacorresistência Bacteriana / Escherichia coli / Infecções por Escherichia coli Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged80 / Female / Humans / Male País/Região como assunto: America do sul / Uruguay Idioma: En Revista: J Glob Antimicrob Resist Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Uruguai País de publicação: Holanda