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Cardiac Autonomic Modulation Is Associated with Arterial Stiffness in Patients with Symptomatic Peripheral Artery Disease.
Germano-Soares, Antonio Henrique; Cucato, Gabriel Grizzo; Leicht, Anthony Scott; Andrade-Lima, Aluísio; Peçanha, Tiago; de Almeida Correia, Marilia; Zerati, Antonio Eduardo; Wolosker, Nelson; Ritti-Dias, Raphael Mendes.
Afiliação
  • Germano-Soares AH; Department of Physical Education, University of Pernambuco, Recife, Pernambuco, Brazil.
  • Cucato GG; Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Leicht AS; Sport and Exercise Science, James Cook University, Townsville, Australia.
  • Andrade-Lima A; Department of Physical Education, Federal University of Sergipe, Sergipe, Brazil.
  • Peçanha T; Department of Physical Education, Federal University of Sergipe, Sergipe, Brazil.
  • de Almeida Correia M; Universidade Nove de Julho, São Paulo, Brazil.
  • Zerati AE; Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
  • Wolosker N; Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Ritti-Dias RM; Universidade Nove de Julho, São Paulo, Brazil. Electronic address: raphaelritti@gmail.com.
Ann Vasc Surg ; 61: 72-77, 2019 Nov.
Article em En | MEDLINE | ID: mdl-31336162
BACKGROUND: The objective of this study was to analyze the association between cardiac autonomic modulation and arterial stiffness in patients with peripheral artery disease (PAD). METHODS: This cross-sectional study included one hundred fourteen patients with symptomatic PAD (67.5% men; 65 ± 7 years; body mass index: 26.8 ± 4.5 kg/m2). Heart rate variability (HRV) was measured within time (standard deviation of all RR intervals [beat to beat heart interval] [SDNN], root mean square of the successive differences between adjacent normal RR intervals [RMSSD], and the proportion of successive RR intervals that differed by more than 50 msec [pNN50]) and frequency (low frequency [LF] and high frequency [HF]) domains. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV). Crude and adjusted linear regression analyses examined the relationship between HRV and cfPWV. RESULTS: Nonsignificant crude associations were identified among cfPWV and RMSSD (P = 0.181), SDNN (P = 0.105), pNN50 (P = 0.087), LF (P = 0.376), HF (P = 0.175), and LF/HF ratio (P = 0.426). After adjustments for age, sex, smoking, body mass index, ankle-brachial index, and use of beta-blockers, significant associations were identified among cfPWV and RMSSD (P = 0.037), SDNN (P = 0.049), and pNN50 (P = 0.049). CONCLUSIONS: Cardiac autonomic modulation was significantly associated with arterial stiffness in patients with PAD after adjustment for confounding factors. This relationship may contribute to the enhanced cardiovascular disease risk for PAD patients and provides a target for strategies to improve patient clinical outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Autônomo / Doença Arterial Periférica / Rigidez Vascular / Coração / Frequência Cardíaca Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Vasc Surg Assunto da revista: ANGIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Autônomo / Doença Arterial Periférica / Rigidez Vascular / Coração / Frequência Cardíaca Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Vasc Surg Assunto da revista: ANGIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda