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Complex I and II are required for normal mitochondrial Ca2+ homeostasis.
Jaña, Fabian; Bustos, Galdo; Rivas, José; Cruz, Pablo; Urra, Felix; Basualto-Alarcón, Carla; Sagredo, Eduardo; Ríos, Melany; Lovy, Alenka; Dong, Zhiwei; Cerda, Oscar; Madesh, Muniswamy; Cárdenas, César.
Afiliação
  • Jaña F; Departamento de Ciencias de la Salud, Universidad de Aysén, Coyhaique, Chile; Geroscience Center for Brain Health and Metabolism, Santiago, Chile.
  • Bustos G; Geroscience Center for Brain Health and Metabolism, Santiago, Chile; Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, Chile.
  • Rivas J; Departamento de Ciencias de la Salud, Universidad de Aysén, Coyhaique, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Santiago, Chile.
  • Cruz P; Geroscience Center for Brain Health and Metabolism, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Santiago, Chile.
  • Urra F; Geroscience Center for Brain Health and Metabolism, Santiago, Chile; Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
  • Basualto-Alarcón C; Departamento de Ciencias de la Salud, Universidad de Aysén, Coyhaique, Chile; Geroscience Center for Brain Health and Metabolism, Santiago, Chile; Anatomy and Legal Medicine Department, Faculty of Medicine, University of Chile, Santiago, Chile.
  • Sagredo E; Centro de Investigación y Tratamiento del Cáncer, Facultad de Medicina, Universidad de Chile, Chile.
  • Ríos M; Geroscience Center for Brain Health and Metabolism, Santiago, Chile.
  • Lovy A; Geroscience Center for Brain Health and Metabolism, Santiago, Chile; Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, Chile; Center for Neuroscience Research, Tufts University School of Medicine, Boston, MA, USA.
  • Dong Z; Department of Medicine, Center for Precision Medicine, University of Texas Health San Antonio, TX, USA.
  • Cerda O; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Santiago, Chile; Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Santiago, Chile.; The Wound Repair, Treatment and Health (WoRTH), Chile.
  • Madesh M; Department of Medicine, Center for Precision Medicine, University of Texas Health San Antonio, TX, USA. Electronic address: muniswamy@uthscsa.edu.
  • Cárdenas C; Geroscience Center for Brain Health and Metabolism, Santiago, Chile; Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, Chile; Buck Institute for Research on Aging, Novato, CA, USA; Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA,
Mitochondrion ; 49: 73-82, 2019 11.
Article em En | MEDLINE | ID: mdl-31310854
Cytosolic calcium (cCa2+) entry into mitochondria is facilitated by the mitochondrial membrane potential (ΔΨm), an electrochemical gradient generated by the electron transport chain (ETC). Is has been assumed that as long as mutations that affect the ETC do not affect the ΔΨm, the mitochondrial Ca2+ (mCa2+) homeostasis remains normal. We show that knockdown of NDUFAF3 and SDHB reduce ETC activity altering mCa2+ efflux and influx rates while ΔΨm remains intact. Shifting the equilibrium toward lower [Ca2+]m accumulation renders cells resistant to death. Our findings reveal an unexpected relationship between complex I and II with the mCa2+ homeostasis independent of ΔΨm.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Succinato Desidrogenase / Cálcio / Proteínas Mitocondriais / Complexo I de Transporte de Elétrons / Homeostase / Mitocôndrias Limite: Humans Idioma: En Revista: Mitochondrion Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Chile País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Succinato Desidrogenase / Cálcio / Proteínas Mitocondriais / Complexo I de Transporte de Elétrons / Homeostase / Mitocôndrias Limite: Humans Idioma: En Revista: Mitochondrion Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Chile País de publicação: Holanda