Complex I and II are required for normal mitochondrial Ca2+ homeostasis.
Mitochondrion
; 49: 73-82, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31310854
Cytosolic calcium (cCa2+) entry into mitochondria is facilitated by the mitochondrial membrane potential (ΔΨm), an electrochemical gradient generated by the electron transport chain (ETC). Is has been assumed that as long as mutations that affect the ETC do not affect the ΔΨm, the mitochondrial Ca2+ (mCa2+) homeostasis remains normal. We show that knockdown of NDUFAF3 and SDHB reduce ETC activity altering mCa2+ efflux and influx rates while ΔΨm remains intact. Shifting the equilibrium toward lower [Ca2+]m accumulation renders cells resistant to death. Our findings reveal an unexpected relationship between complex I and II with the mCa2+ homeostasis independent of ΔΨm.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Succinato Desidrogenase
/
Cálcio
/
Proteínas Mitocondriais
/
Complexo I de Transporte de Elétrons
/
Homeostase
/
Mitocôndrias
Limite:
Humans
Idioma:
En
Revista:
Mitochondrion
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Holanda