Your browser doesn't support javascript.
loading
Association between non-HDL-C/HDL-C ratio and carotid atherosclerosis in postmenopausal middle-aged women.
Masson, W; Epstein, T; Huerín, M; Lobo, M; Molinero, G; Siniawski, D.
Afiliação
  • Masson W; Council of Epidemiology and Cardiovascular Prevention, Argentine Society of Cardiology, Hospital Italiano de Buenos Aires , Buenos Aires , Argentina.
  • Epstein T; Council of Epidemiology and Cardiovascular Prevention, Argentine Society of Cardiology, Hospital Italiano de Buenos Aires , Buenos Aires , Argentina.
  • Huerín M; Council of Epidemiology and Cardiovascular Prevention, Argentine Society of Cardiology, Hospital Italiano de Buenos Aires , Buenos Aires , Argentina.
  • Lobo M; Council of Epidemiology and Cardiovascular Prevention, Argentine Society of Cardiology, Hospital Italiano de Buenos Aires , Buenos Aires , Argentina.
  • Molinero G; Council of Epidemiology and Cardiovascular Prevention, Argentine Society of Cardiology, Hospital Italiano de Buenos Aires , Buenos Aires , Argentina.
  • Siniawski D; Council of Epidemiology and Cardiovascular Prevention, Argentine Society of Cardiology, Hospital Italiano de Buenos Aires , Buenos Aires , Argentina.
Climacteric ; 22(5): 518-522, 2019 10.
Article em En | MEDLINE | ID: mdl-31287342
Background: A novel lipid relation, the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (non-HDL-C/HDL-C) ratio gathers information on all atherogenic and antiatherogenic particles on a single date. The relationship between this lipid marker and the presence of carotid atherosclerotic plaque (CAP) in postmenopausal women is unknown. Methods: Postmenopausal women in primary prevention up to 70 years of age were recruited. Association between the non-HDL-C/HDL-C ratio and presence of CAP, assessed by ultrasonography, was analyzed. Receiver operating characteristic (ROC) curve analysis was performed. Results: A total of 440 females with a mean age of 58.1 ± 5.3 years were recruited. The mean non-HDL-C/HDL ratio was 3.1 ± 1.2 and 28.2% of woman had CAP. A positive relationship was seen between quintiles of the non-HDL-C/HDL-C ratio and prevalence of CAP (p < 0.001). Regardless of other risk factors, women with higher non-HDL-C/HDL-C ratios had a greater chance of having CAP (odds ratio 1.30, 95% confidence interval: 1.07-1.58, p = 0.009). In the ROC curve analysis, the area under the curve of the non-HDL-C/HDL ratio for detecting CAP was 0.703 (95% confidence interval: 0.640-0.765) and the optimal cut-off point was 3.0 (Youden index 0.395). Conclusion: The present study suggests that the non-HDL-C/HDL-C ratio might be a strong marker for predicting the risk of CAP in postmenopausal women.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças das Artérias Carótidas / Pós-Menopausa / HDL-Colesterol Tipo de estudo: Clinical_trials / Diagnostic_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged País/Região como assunto: America do sul / Argentina Idioma: En Revista: Climacteric Assunto da revista: GINECOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças das Artérias Carótidas / Pós-Menopausa / HDL-Colesterol Tipo de estudo: Clinical_trials / Diagnostic_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged País/Região como assunto: America do sul / Argentina Idioma: En Revista: Climacteric Assunto da revista: GINECOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido