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Animal Models of Psychosis in Alzheimer Disease.
Krivinko, Josh M; Koppel, Jeremy; Savonenko, Alena; Sweet, Robert A.
Afiliação
  • Krivinko JM; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.
  • Koppel J; The Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institute for Medical Research, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY.
  • Savonenko A; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD.
  • Sweet RA; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA; Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA. Electronic address: s
Am J Geriatr Psychiatry ; 28(1): 1-19, 2020 01.
Article em En | MEDLINE | ID: mdl-31278012
Psychosis in Alzheimer Disease (AD) represents a distinct clinicopathologic variant associated with increased cognitive and functional morbidity and an accelerated disease course. To date, extant treatments offer modest benefits with significant risks. The development of new pharmacologic treatments for psychosis in AD would be facilitated by validated preclinical models with which to test candidate interventions. The current review provides a brief summary of the process of validating animal models of human disease together with a critical analysis of the challenges posed in attempting to apply those standards to AD-related behavioral models. An overview of phenotypic analogues of human cognitive and behavioral impairments, with an emphasis on those relevant to psychosis, in AD-related mouse models is provided, followed by an update on recent progress in efforts to translate findings in the pathophysiology of psychotic AD into novel models. Finally, some future directions are suggested to expand the catalogue of psychosis-relevant phenotypes that may provide a sturdier framework for model development and targets for preclinical treatment outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Comportamento Animal / Modelos Animais de Doenças / Doença de Alzheimer Tipo de estudo: Etiology_studies / Guideline / Prognostic_studies Limite: Animals Idioma: En Revista: Am J Geriatr Psychiatry Assunto da revista: GERIATRIA / PSIQUIATRIA Ano de publicação: 2020 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Comportamento Animal / Modelos Animais de Doenças / Doença de Alzheimer Tipo de estudo: Etiology_studies / Guideline / Prognostic_studies Limite: Animals Idioma: En Revista: Am J Geriatr Psychiatry Assunto da revista: GERIATRIA / PSIQUIATRIA Ano de publicação: 2020 Tipo de documento: Article País de publicação: Reino Unido