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Human pegivirus-1 (HPgV-1) RNA prevalence and genotypes in volunteer blood donors from the Brazilian Amazon.
Slavov, S N; Maraninchi Silveira, R; Hespanhol, M R; Sauvage, V; Rodrigues, E S; Fontanari Krause, L; Bittencourt, H T; Caro, V; Laperche, S; Covas, D T; Kashima, S.
Afiliação
  • Slavov SN; Regional Blood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14051-140 Ribeirão Preto, São Paulo, Brazil; Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14051-140 Ribeirão Preto, São Paulo, Brazil. Electron
  • Maraninchi Silveira R; Regional Blood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14051-140 Ribeirão Preto, São Paulo, Brazil.
  • Hespanhol MR; Regional Blood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14051-140 Ribeirão Preto, São Paulo, Brazil.
  • Sauvage V; Institut national de la transfusion Sanguine (INTS), département d'études des Agents transmissibles par le sang (DATS), Centre national de référence risques infectieux transfusionnels, 75015 Paris, France.
  • Rodrigues ES; Regional Blood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14051-140 Ribeirão Preto, São Paulo, Brazil.
  • Fontanari Krause L; Laboratory of Biosciences, Franciscan University, 97010-030 Santa Maria, Rio Grande do Sul, Brazil.
  • Bittencourt HT; Institute of Hematology and Hemotherapy of Amapá, 68900-074 Macapá, Amapá, Brazil.
  • Caro V; Pole for Genotyping of Pathogens (PGP), Laboratory for Urgent Response to Biological Threats, Environment and Infectious Risks Research and Expertise Unit, Institut Pasteur, 75724 Paris, France.
  • Laperche S; Institut national de la transfusion Sanguine (INTS), département d'études des Agents transmissibles par le sang (DATS), Centre national de référence risques infectieux transfusionnels, 75015 Paris, France.
  • Covas DT; Regional Blood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14051-140 Ribeirão Preto, São Paulo, Brazil.
  • Kashima S; Regional Blood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14051-140 Ribeirão Preto, São Paulo, Brazil.
Transfus Clin Biol ; 26(4): 234-239, 2019 Nov.
Article em En | MEDLINE | ID: mdl-31277987
OBJECTIVES: The objectives of this study were to evaluate the prevalence of Human Pegivirus-1 (HPgV-1) viremia and genotype diversity among healthy blood donors from the Eastern Brazilian Amazon (city of Macapá, State of Amapá). There is little information for prevalence and circulation of HPgV-1 in this remote Brazilian region. MATERIALS AND METHODS: We conducted a study evaluating the HPgV-1 RNA prevalence and circulating genotypes in 431 volunteer blood donors originating from the Eastern Brazilian Amazon. The obtained HPgV-1 positive samples were submitted to sequencing and genotyping analysis in order to examine the genotype diversity of this virus in the Brazilian Amazon. RESULTS: Our results demonstrated a prevalence of HPgV-1 RNA in 9.5% of the tested blood donors. The phylogenetic analyses of the detected positive samples showed the presence of HPgV-1 genotypes 1, 2 and 3. The most frequently detected genotype was 2 (78.0% of the cases) represented by sub-genotypes 2A (39.0%) and 2B (39.0%). At lower rates, genotypes 1 (14.6%) and 3 (7.4%) were also detected. CONCLUSION: Our results revealed the presence of genotypes with European, Asiatic and African endemicity in Amazonian blood donors, probably due to the complex miscegenation processes that took place in this Brazilian region. More investigations, including information for the prevalence of HPgV-1 RNA in blood donors from other Latin American countries are needed to estimate the viremic rates and genotype distribution of this virus in a highly diverse continent like South America.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doadores de Sangue / RNA Viral / Infecções por Flaviviridae / Vírus GB C / Hepatite Viral Humana Tipo de estudo: Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Região como assunto: Africa / America do sul / Asia / Brasil / Europa Idioma: En Revista: Transfus Clin Biol Assunto da revista: HEMATOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de publicação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doadores de Sangue / RNA Viral / Infecções por Flaviviridae / Vírus GB C / Hepatite Viral Humana Tipo de estudo: Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Região como assunto: Africa / America do sul / Asia / Brasil / Europa Idioma: En Revista: Transfus Clin Biol Assunto da revista: HEMATOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de publicação: França