Nucleoside Analogs with Antiviral Activity against Yellow Fever Virus.
Antimicrob Agents Chemother
; 63(9)2019 09.
Article
em En
| MEDLINE
| ID: mdl-31262759
Yellow fever virus (YFV) is a human Flavivirus reemerging in parts of the world. While a vaccine is available, large outbreaks have recently occurred in Brazil and certain African countries. Development of an effective antiviral against YFV is crucial, as there is no available effective drug against YFV. We have identified several novel nucleoside analogs with potent antiviral activity against YFV with 50% effective concentration (EC50) values between 0.25 and 1 µM with selectivity indices over 100 in culture.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Febre Amarela
/
Vírus da Febre Amarela
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Nucleosídeos
Limite:
Animals
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Humans
País/Região como assunto:
Africa
/
America do sul
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Brasil
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Estados Unidos