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Effects of inactivation of the ventral tegmental area on prefronto-accumbens activity and sexual motivation in male rats.
Cortes, Pedro Manuel; Hernández-Arteaga, Enrique; Sotelo-Tapia, Carolina; Guevara, Miguel Angel; Medina, Andrea Cristina; Hernández-González, Marisela.
Afiliação
  • Cortes PM; Instituto de Neurociencias, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
  • Hernández-Arteaga E; Instituto de Neurociencias, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
  • Sotelo-Tapia C; Instituto de Neurociencias, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
  • Guevara MA; Instituto de Neurociencias, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
  • Medina AC; Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico.
  • Hernández-González M; Instituto de Neurociencias, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico. Electronic address: mariselh@cencar.udg.mx.
Physiol Behav ; 209: 112593, 2019 10 01.
Article em En | MEDLINE | ID: mdl-31255646
Sexual motivation requires the processing of sexual stimuli. The prefrontal cortex (PFC) and nucleus accumbens (NAcc) receive dopaminergic innervation from the ventral tegmental area (VTA). Both structures participate in processing stimuli, and their adequate functioning is modulated by dopamine and other neurotransmitters. This study was designed to determine the effect of inactivation of the VTA on sexual motivation, relative power (RP) and electroencephalographic (EEG) correlation of the PFC and NAcc in male rats. A total of 20 rats implanted with electrodes in the left medial prefrontal cortex (mPFC) and NAcc, and with bilateral cannulae in the VTA, were divided into two groups of 10 rats each, one injected with tetrodotoxin (TTX), the other with a vehicle solution (VEH). EEGs from the mPFC and NAcc were recorded during the awake-quiet state in the presence of either a receptive or non-receptive female. The TTX group showed a lower preference for the receptive female accompanied by a lower RP of the 8-13 and 14-30 Hz bands in the mPFC. Also, in the presence of the receptive female, the TTX group had a lower RP of the 8-13 Hz band in the NAcc, but a higher prefronto-accumbens correlation in the same band. These results provide evidence that VTA activity is necessary for the adequate functioning of the mPFC and NAcc and, therefore, also for the adequate processing of sexually-relevant stimuli that allows the induction and maintenance of sexual motivation in male rats.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Sexual Animal / Córtex Pré-Frontal / Área Tegmentar Ventral / Núcleo Accumbens Limite: Animals Idioma: En Revista: Physiol Behav Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Sexual Animal / Córtex Pré-Frontal / Área Tegmentar Ventral / Núcleo Accumbens Limite: Animals Idioma: En Revista: Physiol Behav Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos