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Trans-fatty acids aggravate anabolic steroid-induced metabolic disturbances and differential gene expression in muscle, pancreas and adipose tissue.
Gonçalves, Reggiani V; Santos, Jamili D B; Silva, Natanny S; Guillocheau, Etienne; Silva, Robson E; Souza-Silva, Thaiany G; Oliveira, Rafael F; Santos, Eliziária C; Novaes, Romulo D.
Afiliação
  • Gonçalves RV; Department of Animal Biology, Federal University of Viçosa, 36570-000, Minas Gerais, Brazil.
  • Santos JDB; Institute of Biomedical Sciences, Department of Structural Biology, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil.
  • Silva NS; Institute of Biomedical Sciences, Department of Structural Biology, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil.
  • Guillocheau E; Laboratory of Biochemistry and Human Nutrition, Agrocampus-Ouest, 35042, Rennes, France.
  • Silva RE; School of Medicine, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil.
  • Souza-Silva TG; Institute of Biomedical Sciences, Department of Structural Biology, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil.
  • Oliveira RF; Institute of Biomedical Sciences, Department of Structural Biology, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil; School of Dentistry, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil.
  • Santos EC; School of Medicine, Federal University of Jequitinhonha and Mucuri Valleys, 39100-000, Minas Gerais, Brazil.
  • Novaes RD; Institute of Biomedical Sciences, Department of Structural Biology, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil. Electronic address: romulo.novaes@unifal-mg.edu.br.
Life Sci ; 232: 116603, 2019 Sep 01.
Article em En | MEDLINE | ID: mdl-31254587
AIMS: Although anabolic steroids (AS) and trans-fatty acids overload exerts systemic toxicity and are independent risk factors for metabolic and cardiovascular disorders, their interaction remains poorly understood. Thus, we investigated the impact of a diet rich in trans-fatty acids (HFD) combined with AS on glycemic control, lipid profile, adipose tissue, skeletal muscle and pancreas microstructure and expression of genes involved in energy metabolism. MAIN METHODS: Forty-eight C57BL/6 mice were randomized into 6 groups treated for 12 weeks with a standard diet (SD) or a diet rich in C18:1 trans-fatty isomers (HFD), alone or combined with 10 or 20 mg/kg testosterone cypionate (AS). KEY FINDINGS: Our results indicated that AS improved glycemic control, upregulated gene expression of Glut-4 and CPT-1 in skeletal muscle, FAS, ACC and UCP-1 in adipose tissue. AS also reduced total and LDL cholesterol in mice fed a SD. When combined with the HFD, AS was unable to induce microstructural adaptations in adipose tissue, pancreatic islets and ß-cells, but potentiated GCK and Glut-2 (pancreas) and Glut-4 and CPT-1 (skeletal muscle) upregulation. HFD plus AS also downregulated FAS and ACC gene expression in adipose tissue. Combined with HFD, AS increased triacylglycerol circulating levels, improved insulin sensitivity and glycemic control in mice. SIGNIFICANCE: Our findings indicated that HFD and AS can interact to modulates glycemic control and lipid profile by a mechanism potentially related with a reprogramming of genes expression in organs such as the pancreas, adipose tissue and skeletal muscle.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Congêneres da Testosterona / Ácidos Graxos trans Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Congêneres da Testosterona / Ácidos Graxos trans Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda