Evolution of the Liquid Biopsy in Metastatic Prostate Cancer.
Urology
; 132: 1-9, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-31207303
We reviewed the literature for the biologic, prognostic, and predictive significance of circulating prostate cancer tumor cells (CTCs), and circulating tumor DNA in the blood of metastatic castration resistant prostate cancer patients. CTCs demonstrate robust prognostic value independent of PSA in predicting overall survival. The CTC androgen receptor variant receptor 7 phenotype predicts resistance to androgen receptor synthesis inhibitors and sensitivity to taxane based chemotherapy in metastatic castration resistant prostate cancer patients who are candidates for second line therapy. Research is rapidly pivoting toward circulating tumor DNA analysis because the approach is sensitive, prognostic, cost effective, and it can elucidate mechanisms of systemic therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA de Neoplasias
/
Neoplasias de Próstata Resistentes à Castração
/
Células Neoplásicas Circulantes
Limite:
Humans
/
Male
Idioma:
En
Revista:
Urology
Ano de publicação:
2019
Tipo de documento:
Article
País de publicação:
Estados Unidos