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Prevalence and Temporal Distribution of Fast and Slow Progressors of Infarct Growth in Large Vessel Occlusion Stroke.
Rocha, Marcelo; Desai, Shashvat M; Jadhav, Ashutosh P; Jovin, Tudor G.
Afiliação
  • Rocha M; From the Department of Neurology (M.R., S.M.D., A.P.J.), University of Pittsburgh Medical Center, PA.
  • Desai SM; From the Department of Neurology (M.R., S.M.D., A.P.J.), University of Pittsburgh Medical Center, PA.
  • Jadhav AP; From the Department of Neurology (M.R., S.M.D., A.P.J.), University of Pittsburgh Medical Center, PA.
  • Jovin TG; Department of Neurosurgery (A.P.J.), University of Pittsburgh Medical Center, PA.
Stroke ; 50(8): 2238-2240, 2019 08.
Article em En | MEDLINE | ID: mdl-31203787
Background and Purpose- Fast and slow progressors of infarct growth due to anterior circulation large vessel occlusion are commonly observed in clinical practice. We aimed to estimate the prevalence and temporal distribution of fast and slow progressors among anterior circulation large vessel occlusion patients diagnosed within 24 hours of stroke onset. Methods- Single-center retrospective study of all patients with anterior circulation large vessel occlusion who underwent baseline computed tomographic perfusion or magnetic resonance imaging within 24 hours of stroke onset. Prevalence was determined for fast progressors (ischemic core >70 mL, <6 hours of stroke onset) and slow progressors (ischemic core ≤30 mL, >6-24 hours of stroke onset). Results- One hundred eighty-five patients were included. The median time interval from stroke onset to baseline core imaging was 7.6 hours (interquartile range, 3.9-13.2), and median core volume was 17 mL (range, 0-405). Patients had core volume ≤70 mL in 72% of cases in the overall cohort. The prevalence of fast progressors was 25% (95% CI, 17%-37%) and reached 40% (95% CI, 24%-59%) between 3 and 4.5 hours after stroke onset. The prevalence of slow progressors was 55% (95% CI, 46%-64%) and was similar across time intervals beyond 6 hours after stroke onset. Conclusions- Most anterior circulation large vessel occlusion patients had small-to-moderate ischemic core volume, irrespective of early or delayed presentation within 24 hours of stroke onset. Fast progressors were highly prevalent between 3 and 4.5 hours after stroke onset.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arteriopatias Oclusivas / Encéfalo / Isquemia Encefálica / Acidente Vascular Cerebral Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Stroke Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arteriopatias Oclusivas / Encéfalo / Isquemia Encefálica / Acidente Vascular Cerebral Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Stroke Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos