Effects of ecologically relevant concentrations of Boral® 500 SC, Glifosato® Biocarb, and a blend of both herbicides on markers of metabolism, stress, and nutritional condition factors in bullfrog tadpoles.
Environ Sci Pollut Res Int
; 26(23): 23242-23256, 2019 Aug.
Article
em En
| MEDLINE
| ID: mdl-31190300
The aim of this study was to verify the effects of the isolated forms of Boral® SC 500, Glifosato® Biocarb herbicides, and a blend of both herbicides on metabolism and oxidative balance markers of Rana catesbeiana tadpoles and on their nutritional condition. Groups of tadpoles were divided into different treatments: control (no herbicides), Boral® 500 SC (sulfentrazone: 130 µg/L), Glifosato® Biocarb (glyphosate: 234 µg/L), and a blend of both herbicides. After 7 days, the liver, caudal muscle, and blood samples were taken to subsequently perform the biomarkers determination by spectrophotometry. The intestinal condition factor increased in animals exposed to glyphosate and herbicide blends, suggesting a hyperphagic effect. This hypothesis was confirmed by the rise of triglycerides and circulating very low-density lipoprotein (VLDL). There was a significant increase in the levels of uric acid in tadpoles exposed to the herbicide blend. Corticosterone levels reduced significantly in animals exposed to glyphosate and the herbicide blend. Oxidative stress markers had a tissue-dependent response. In the liver, glutathione S-transferase increased, and superoxide dismutase and catalase decreased in animals exposed to sulfentrazone and glyphosate. Lipoperoxidation was reduced in the glyphosate treatment. In the caudal muscle, superoxide dismutase and catalase activities were maintained, and there was a decline in the levels of glutathione S-transferase and TBARS only in the blend group.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
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Triazóis
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Poluentes Químicos da Água
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Estresse Oxidativo
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Glicina
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Herbicidas
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Larva
Limite:
Animals
Idioma:
En
Revista:
Environ Sci Pollut Res Int
Assunto da revista:
SAUDE AMBIENTAL
/
TOXICOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Alemanha