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CCR5 genetic variants and epidemiological determinants for HPV infection and cervical premalignant lesions.
Mangieri, Luis Fernando L; Sena, Michelle M; Cezar-Dos-Santos, Fernando; Trugilo, Kleber P; Okuyama, Nádia C M; Pereira, Érica R; Maria, Gabriela C Q; Watanabe, Maria Angelica E; de Oliveira, Karen B.
Afiliação
  • Mangieri LFL; Laboratory of Molecular Genetics and Immunology, Department of Pathological Science, Londrina State University, Londrina, Brazil.
  • Sena MM; Laboratory of Molecular Genetics and Immunology, Department of Pathological Science, Londrina State University, Londrina, Brazil.
  • Cezar-Dos-Santos F; Laboratory of Molecular Genetics and Immunology, Department of Pathological Science, Londrina State University, Londrina, Brazil.
  • Trugilo KP; Laboratory of Molecular Genetics and Immunology, Department of Pathological Science, Londrina State University, Londrina, Brazil.
  • Okuyama NCM; Laboratory of Molecular Genetics and Immunology, Department of Pathological Science, Londrina State University, Londrina, Brazil.
  • Pereira ÉR; Laboratory of Molecular Genetics and Immunology, Department of Pathological Science, Londrina State University, Londrina, Brazil.
  • Maria GCQ; Laboratory of Molecular Genetics and Immunology, Department of Pathological Science, Londrina State University, Londrina, Brazil.
  • Watanabe MAE; Laboratory of Study and Application of DNA Polymorphism, Department of Pathological Science, Londrina State University, Londrina, Brazil.
  • de Oliveira KB; Laboratory of Molecular Genetics and Immunology, Department of Pathological Science, Londrina State University, Londrina, Brazil.
Int J Immunogenet ; 46(5): 331-338, 2019 Oct.
Article em En | MEDLINE | ID: mdl-31183980
Human papillomavirus (HPV) infection can lead to the development of productive epithelial lesions and cervical cancer. Most cervical HPV infections are solved by cell-mediated immunity within 1-2 years, and it is known that chronic inflammation predisposes to lesions progression and tumour development. In this context, we highlight the CC chemokine receptor 5 (CCR5) which is involved in leucocytes chemotaxis to sites of inflammation, controlling the immune response. The CCR5 rs333 genotyping of 164 HPV infected women and 185 non-infected women was performed using polymerase chain reaction (PCR). HPV infection was more frequent among women under 34 years old (p < 0.001), single (p = 0.001), that received 1 minimum wage or less (p = 0.002), tobacco smokers (p = 0.007), who had the first sexual intercourse before 17 years old (p = 0.038) and that had 4 or more sexual partners during lifetime (p = 0.001). No significant difference regarding genotypes and alleles distribution according to HPV infection was observed. CCR5/CCR5 genotype was observed in 94.1% of HPV non-infected women and in 89% of infected ones, CCR5/Δ32 in 5.9% of HPV infected and in 10.4% of non-infected women, and Δ32/Δ32 was observed in only one (0.6%) infected patient. CCR5 genotypes were also not associated with cervical lesions development among HPV infected women (p = 0.167). Since CCR5 may control the antitumour immune response and cervical lesions and the studied rs333 polymorphism is not very frequent, other studies are necessary, in order to establish CCR5 role on HPV infection and squamous intraepithelial lesions development.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Displasia do Colo do Útero / Neoplasias do Colo do Útero / Receptores CCR5 / Infecções por Papillomavirus Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int J Immunogenet Assunto da revista: ALERGIA E IMUNOLOGIA / GENETICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Displasia do Colo do Útero / Neoplasias do Colo do Útero / Receptores CCR5 / Infecções por Papillomavirus Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int J Immunogenet Assunto da revista: ALERGIA E IMUNOLOGIA / GENETICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido