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Quality Assessment of Dried Blood Spots from Patients With Tuberculosis from 4 Countries.
Zuur, Marlanka A; Veenhof, Herman; Aleksa, Alena; Vanʼt Boveneind-Vrubleuskaya, Natascha; Darmawan, Endang; Hasnain, Md Golam; Heysell, Scott K; Jongedijk, Erwin M; Koster, Remco A; Magis-Escurra, Cecile; Martinez, Nilza; Molinas, Gladys; Mondal, Dinesh; Mulyani, Ully A; Perwitasari, Dyah A; Tsivunchyk, Andrej; Touw, Daan J; Alffenaar, Jan-Willem C.
Afiliação
  • Zuur MA; Department Clinical Pharmacy and Pharmacology, University of Groningen, Groningen, the Netherlands.
  • Veenhof H; Department Clinical Pharmacy and Pharmacology, University of Groningen, Groningen, the Netherlands.
  • Aleksa A; Department of Phthisiology and Pulmonology, Grodno State Medical University, Grodno, Belarus.
  • Vanʼt Boveneind-Vrubleuskaya N; Department of TB Control, Metropolitan Public Health Service Haaglanden, The Hague, the Netherlands.
  • Darmawan E; Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, Indonesia.
  • Hasnain MG; Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B), Dhaka, Bangladesh.
  • Heysell SK; Centre for Clinical Epidemiology and Biostatistics (CCEB), School of Medicine and Public Health (SMPH), Faculty of Health and Medicine, The University of Newcastle (UoN), New South Wales, Australia.
  • Jongedijk EM; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia.
  • Koster RA; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Clinical Pharmaceutical and Toxicological Laboratory, Groningen.
  • Magis-Escurra C; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Clinical Pharmaceutical and Toxicological Laboratory, Groningen.
  • Martinez N; PRA Health Sciences Bioanalytical Laboratory, Assen.
  • Molinas G; Department of Respiratory Diseases, Radboud University Medical Center-TB Expert Centre Dekkerswald, Nijmegen-Groesbeek, the Netherlands.
  • Mondal D; Instituto Nacional de Enfermedades Respiratorias y del Ambiente, Asunción, Paraguay.
  • Mulyani UA; Instituto Nacional de Enfermedades Respiratorias y del Ambiente, Asunción, Paraguay.
  • Perwitasari DA; Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B), Dhaka, Bangladesh.
  • Tsivunchyk A; Indonesia Agency for Health Research and Development, Ministry of Health, Jakarta, Indonesia.
  • Touw DJ; Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, Indonesia.
  • Alffenaar JC; Department of Phthisiology and Pulmonology, Grodno State Medical University, Grodno, Belarus.
Ther Drug Monit ; 41(6): 714-718, 2019 12.
Article em En | MEDLINE | ID: mdl-31169760
BACKGROUND: Dried blood spot (DBS) sampling is a blood collection tool that uses a finger prick to obtain a blood drop on a DBS card. It can be used for therapeutic drug monitoring, a method that uses blood drug concentrations to optimize individual treatment. DBS sampling is believed to be a simpler way of blood collection compared with venous sampling. The aim of this study was to evaluate the quality of DBSs from patients with tuberculosis all around the world based on quality indicators in a structured assessment procedure. METHODS: Total 464 DBS cards were obtained from 4 countries: Bangladesh, Belarus, Indonesia, and Paraguay. The quality of the DBS cards was assessed using a checklist consisting of 19 questions divided into 4 categories: the integrity of the DBS materials, appropriate drying time, blood volume, and blood spot collection. RESULTS: After examination, 859 of 1856 (46%) blood spots did not comply with present quality criteria. In 625 cases (34%), this was due to incorrect blood spot collection. The DBS cards from Bangladesh, Indonesia, and Paraguay seemed to be affected by air humidity, causing the blood spots not to dry appropriately. CONCLUSIONS: New tools to help obtain blood spots of sufficient quality are necessary and environmental specific recommendations to determine plasma concentration correctly. In addition, 3% of the DBS cards were rejected because the integrity of the materials suggesting that the quality of plastic ziplock bags currently used to protect the DBS cards against contamination and humidity may not be sufficient.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Manejo de Espécimes / Tuberculose / Monitoramento de Medicamentos / Teste em Amostras de Sangue Seco / Antituberculosos Tipo de estudo: Diagnostic_studies / Guideline Limite: Humans País/Região como assunto: America do sul / Asia / Europa / Paraguay Idioma: En Revista: Ther Drug Monit Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Manejo de Espécimes / Tuberculose / Monitoramento de Medicamentos / Teste em Amostras de Sangue Seco / Antituberculosos Tipo de estudo: Diagnostic_studies / Guideline Limite: Humans País/Região como assunto: America do sul / Asia / Europa / Paraguay Idioma: En Revista: Ther Drug Monit Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda País de publicação: Estados Unidos