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Exercise and Sirtuins: A Way to Mitochondrial Health in Skeletal Muscle.
Vargas-Ortiz, Katya; Pérez-Vázquez, Victoriano; Macías-Cervantes, Maciste H.
Afiliação
  • Vargas-Ortiz K; Department of Medical Sciences, University of Guanajuato, Campus León, 37220 Guanajuato, Mexico. kavati75@hotmail.com.
  • Pérez-Vázquez V; Department of Medical Sciences, University of Guanajuato, Campus León, 37220 Guanajuato, Mexico. vicpe@yahoo.com.
  • Macías-Cervantes MH; Department of Medical Sciences, University of Guanajuato, Campus León, 37220 Guanajuato, Mexico. mh.macias@ugto.mx.
Int J Mol Sci ; 20(11)2019 Jun 03.
Article em En | MEDLINE | ID: mdl-31163574
The sirtuins form a family of evolutionarily conserved nicotinamide adenine dinucleotide (NAD)-dependent deacetylases. Seven sirtuins (SIRT1-SIRT7) have been described in mammals, with specific intracellular localization and biological functions associated with mitochondrial energy homeostasis, antioxidant activity, proliferation and DNA repair. Physical exercise affects the expression of sirtuin in skeletal muscle, regulating changes in mitochondrial biogenesis, oxidative metabolism and the cellular antioxidant system. In this context, sirtuin 1 and sirtuin 3 have been the most studied. This review focuses on the effects of different types of exercise on these sirtuins, the molecular pathways involved and the biological effect that is caused mainly in healthy subjects. The reported findings suggest that an acute load of exercise activates SIRT1, which in turn activates biogenesis and mitochondrial oxidative capacity. Additionally, several sessions of exercise (training) activates SIRT1 and also SIRT3 that, together with the biogenesis and mitochondrial oxidative function, jointly activate ATP production and the mitochondrial antioxidant function.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exercício Físico / Músculo Esquelético / Sirtuínas / Mitocôndrias Musculares Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exercício Físico / Músculo Esquelético / Sirtuínas / Mitocôndrias Musculares Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: Suíça