Your browser doesn't support javascript.
loading
α7 nicotinic ACh receptors are necessary for memory recovery and neuroprotection promoted by attention training in amyloid-ß-infused mice.
Telles-Longui, Milena; Mourelle, Danilo; Schöwe, Natalia Mendes; Cipolli, Gabriela Cabett; Malerba, Helena Nascimento; Buck, Hudson Sousa; Viel, Tania Araujo.
Afiliação
  • Telles-Longui M; Graduate Course on Pharmacology, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo, Brazil.
  • Mourelle D; Graduate Course on Pharmacology, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo, Brazil.
  • Schöwe NM; Graduate Course on Pharmacology, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo, Brazil.
  • Cipolli GC; Research Group on Neuropharmacology of Aging, São Paulo, Brazil.
  • Malerba HN; School of Arts, Sciences and Humanities, Universidade de São Paulo, São Paulo, Brazil.
  • Buck HS; Graduate Course on Pharmacology, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo, Brazil.
  • Viel TA; Research Group on Neuropharmacology of Aging, São Paulo, Brazil.
Br J Pharmacol ; 176(17): 3193-3205, 2019 09.
Article em En | MEDLINE | ID: mdl-31144293
BACKGROUND AND PURPOSE: Attention training reverses the neurodegeneration and memory loss promoted by infusion of amyloid-ß (Aß) peptide in rats and increases the density of α7 nicotinic ACh receptors (α7nAChRs) in brain areas related to memory. Hence, we aimed to assess the role of α7nAChRs in the memory recovery promoted by attention training. EXPERIMENTAL APPROACH: C57Bl/6 mice were chronically infused with Aß, Aß plus the α7 antagonist methyllycaconitine (MLA), or MLA alone. Control animals were infused with vehicle. Animals were subjected weekly to the active avoidance shuttle box for 4 weeks (attention training). The brain and serum were collected for biochemical and histological analysis. KEY RESULTS: Aß caused cognitive impairment, which was reversed by the weekly training, whereas Aß + MLA also promoted memory loss but with no reversal with weekly training. MLA alone also promoted memory loss but with only partial reversal with the training. Animals infused with Aß alone showed senile plaques in hippocampus, no change in BDNF levels in cortex, hippocampus, and serum, but increased AChE activity in cortex and hippocampus. Co-treatment with MLA increased AChE activity and senile plaque deposition in hippocampus as well as reducing BDNF in hippocampus and serum, suggesting a lack of α7nAChR function leads to a loss of neuroprotection mechanisms. CONCLUSIONS AND IMPLICATIONS: The α7nAChR has a determinant role in memory recovery and brain resilience in the presence of neurodegeneration promoted by Aß peptide. These data support further studies concerning these receptors as pharmacological targets for future therapies.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Receptor Nicotínico de Acetilcolina alfa7 / Memória Limite: Animals Idioma: En Revista: Br J Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Receptor Nicotínico de Acetilcolina alfa7 / Memória Limite: Animals Idioma: En Revista: Br J Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido