CB1R mediates oleamide's reward while 5HT2cR mediates aversion in the nucleus accumbens shell of rats.
Neurosci Lett
; 706: 189-193, 2019 07 27.
Article
em En
| MEDLINE
| ID: mdl-31116971
In this study, we have pursued to assess oleamide's potential role in reward and aversion mechanisms. To reach this goal we infused oleamide, either 1 µg into the nucleus accumbens shell (NAccS) and evaluated its effects on conditioned place preference (CCP) or 10 µg, to evaluate conditioned place aversion (CPA). Extinction and reinstatement were also evaluated in both cases. We sought to determine if CPP occurs via cannabinoid receptor 1 (CB1R) and CPA via serontoninergic 2c receptor (5HT2cR). Results revealed that 1 µg of oleamide administered bilaterally into the NAccS induced CPP, while 10 µg induced CPA. In both conditions CPP or CPA, reinstatement after extinction was induced. AM251 (CB1R inverse-agonist) prevented CPP induced with 1 µg; while SB242084 (5HT2cR antagonist) not only prevented CPA induced with 10 µg but caused a switch to CPP. These results suggest that oleamide at low doses promotes reward through CB1R, and aversion at high doses via 5HT2cR.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recompensa
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Ácidos Oleicos
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Condicionamento Operante
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Receptor CB1 de Canabinoide
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Receptor 5-HT2C de Serotonina
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Núcleo Accumbens
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Irlanda