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Antifungal activity and Shore A hardness of a tissue conditioner incorporated with terpinen-4-ol and cinnamaldehyde.
de Fátima Souto Maior, Laura; Maciel, Panmella Pereira; Ferreira, Victor Yuri Nicolau; de Lima Gouveia Dantas, Cíntia; de Lima, Jeferson Muniz; Castellano, Lúcio Roberto Cançado; Batista, André Ulisses Dantas; Bonan, Paulo Rogério Ferreti.
Afiliação
  • de Fátima Souto Maior L; School of Dentistry, Federal University of Paraiba, Castelo Branco, Joao Pessoa, Paraiba, Brazil. laurasoutomaior.lsm@gmail.com.
  • Maciel PP; Dentistry Post-Graduation Program, Federal University of Paraiba, Campus I / Cidade Universitaria, Joao Pessoa, Paraiba, Brazil. laurasoutomaior.lsm@gmail.com.
  • Ferreira VYN; School of Dentistry, Federal University of Paraiba, Castelo Branco, Joao Pessoa, Paraiba, Brazil.
  • de Lima Gouveia Dantas C; Dentistry Post-Graduation Program, Federal University of Paraiba, Campus I / Cidade Universitaria, Joao Pessoa, Paraiba, Brazil.
  • de Lima JM; School of Dentistry, Federal University of Paraiba, Castelo Branco, Joao Pessoa, Paraiba, Brazil.
  • Castellano LRC; Dentistry Post-Graduation Program, Federal University of Paraiba, Campus I / Cidade Universitaria, Joao Pessoa, Paraiba, Brazil.
  • Batista AUD; School of Dentistry, Federal University of Paraiba, Castelo Branco, Joao Pessoa, Paraiba, Brazil.
  • Bonan PRF; Dentistry Post-Graduation Program, Federal University of Paraiba, Campus I / Cidade Universitaria, Joao Pessoa, Paraiba, Brazil.
Clin Oral Investig ; 23(7): 2837-2848, 2019 Jul.
Article em En | MEDLINE | ID: mdl-31111285
PURPOSE: This study investigated the anti-Candida activity and the Shore A hardness of a tissue conditioner (Softone™) modified by incorporation of terpinen-4-ol and cinnamaldehyde. MATERIAL AND METHODS: Agar diffusion, microdilution, and mechanism of action methods were performed to determine to evaluate the antifungal activity of phytoconstituents. Then, phytoconstituents in varying concentrations were incorporated into the tissue conditioner. The anti-Candida effect of the modified conditioner was evaluated through agar punch well and biofilm formation methods. Shore A hardness of the experimental liners was evaluated after baseline, 24 h, 48 h, 4 days, and 7 days immersion on artificial saliva. RESULTS: The phytoconstituents incorporated into Softone showed completely inhibited fungal growth in concentrations of 20-40% and did not present significant antifungal activity until their concentrations where higher than 5%. There were differences between non-modified Softone and M5, M10, C10, and T10% (p < 0.05). The groups containing 10-40% of cinnamaldehyde incorporated into Softone were able to completely inhibit the biofilm. Concentrations below 40% of terpinen-4-ol showed unsatisfactory biofilm inhibition. The T40% and C40% groups presented the lowest Shore A hardness values. Hardness values from groups T40% at 7 days (p = 0.476); C40% at 4 days (p = 0.058); and T20% (p = 0.058), C20% (p = 0.205), T30% (p = 0.154), and C30% (p = 0.874) after 48 h did not differ from the control group. CONCLUSIONS: Cinnamaldehyde incorporated into Softone inhibited Candida biofilm formation at concentrations of 10-40%, being more effective than terpinen-4-ol modification despite of halo inhibition observed by both products. CLINICAL RELEVANCE: All modifications showed a very similar pattern of hardness being useful for clinical practice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terpenos / Acroleína / Candida albicans / Antifúngicos Idioma: En Revista: Clin Oral Investig Assunto da revista: ODONTOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terpenos / Acroleína / Candida albicans / Antifúngicos Idioma: En Revista: Clin Oral Investig Assunto da revista: ODONTOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha