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Synergistic anti-tumor effect of paclitaxel and miR-34a combined with ultrasound microbubbles on cervical cancer in vivo and in vitro.
Yu, J; Zhao, Y; Liu, C; Hu, B; Zhao, M; Ma, Y; Jiang, J.
Afiliação
  • Yu J; Medical College of China, Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Three Gorges University, Yichang, 443002, Hubei Province, China.
  • Zhao Y; Department of Ultrasonography, Hubei Cancer Hospital, Wuhan, 430079, Hubei Province, China.
  • Liu C; Medical College of China, Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Three Gorges University, Yichang, 443002, Hubei Province, China. zhaoyun@ctgu.edu.cn.
  • Hu B; Medical College of China, Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Three Gorges University, Yichang, 443002, Hubei Province, China.
  • Zhao M; Department of Ultrasonography, The Second Clinical Medical College of China, Three Gorges University, Yichang, 443002, Hubei Province, China.
  • Ma Y; Medical College of China, Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Three Gorges University, Yichang, 443002, Hubei Province, China.
  • Jiang J; Medical College of China, Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Three Gorges University, Yichang, 443002, Hubei Province, China.
Clin Transl Oncol ; 22(1): 60-69, 2020 Jan.
Article em En | MEDLINE | ID: mdl-31093891
PURPOSE: Improved therapeutic options for cervical cancer are needed. The purpose of this study was to evaluate the synergetic, inhibitory effects of ultrasound-mediated paclitaxel (PTX)- and miR-34a-loaded microbubbles (MBs) on cervical cancer. METHODS: U14 cervical cancer cells and xenograft mouse tumors were treated with PTX-miR-34a-MBs. RESULTS: Levels of miR-34a increased in vitro and vivo after treatment with ultrasound-mediated PTX-miR-34a-MBs. Furthermore, this treatment decreased the proliferation of cervical cancer cells, microvessel density, and the expression of Bcl-2 and CDK6, both in vitro and in vivo. Furthermore, Bax expression was increased in the in vivo model. And, tumor volume and weight were significantly reduced by 78.57% and 87.97%, respectively (P < 0.01). CONCLUSIONS: These results indicate that ultrasound-mediated PTX-miR-34a-MBs synergistically inhibit the growth of cervical cancer via the upregulation of miR-34a and downregulation of Bcl-2 and CDK6. Thus, PTX-miR-34a-MBs in combination with ultrasound microbubbles are a promising anticancer delivery strategy for treating cervical cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Ultrassonografia / Paclitaxel / MicroRNAs / Microbolhas / Sinergismo Farmacológico Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Itália
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Ultrassonografia / Paclitaxel / MicroRNAs / Microbolhas / Sinergismo Farmacológico Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Itália