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Sex differences in behavior and neuropharmacology of zebrafish.
Genario, Rafael; de Abreu, Murilo S; Giacomini, Ana C V V; Demin, Konstantin A; Kalueff, Allan V.
Afiliação
  • Genario R; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
  • de Abreu MS; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
  • Giacomini ACVV; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, Louisiana.
  • Demin KA; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
  • Kalueff AV; Postgraduate Program in Environmental Sciences, University of Passo Fundo (UPF), Passo Fundo, Brazil.
Eur J Neurosci ; 52(1): 2586-2603, 2020 07.
Article em En | MEDLINE | ID: mdl-31090957
Sex is an important variable in biomedical research. The zebrafish (Danio rerio) is increasingly utilized as a powerful new model organism in translational neuroscience and pharmacology. Mounting evidence indicates important sex differences in zebrafish behavioral and neuropharmacological responses. Here, we discuss the role of sex in zebrafish central nervous system (CNS) models, their molecular mechanisms, recent findings and the existing challenges in this field. We also emphasize the growing utility of zebrafish models in translational neuropharmacological research of sex differences, fostering future CNS drug discovery and the search for novel sex-specific therapies. Finally, we highlight the interplay between sex and environment in zebrafish models of sex-environment correlations as an important strategy of CNS disease modeling using this aquatic organism.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Neurociências Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Eur J Neurosci Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Neurociências Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Eur J Neurosci Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: França