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Effects of Subcutaneous Ochratoxin-A Exposure on Immune System of Broiler Chicks.
Khan, Shahzad Akbar; Venancio, Emerson J; Ono, Mario A; Fernandes, Eduardo V; Hirooka, Elisa Y; Shimizu, Cleverson F; Oba, Alexandre; Flaiban, Karina K M C; Itano, Eiko N.
Afiliação
  • Khan SA; Department of Pathologic Sciences, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. shahzadakbar@upr.edu.pk.
  • Venancio EJ; Department of Pathologic Sciences, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. emersonj@uel.br.
  • Ono MA; Department of Pathologic Sciences, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. marioono@uel.br.
  • Fernandes EV; Department of Pathologic Sciences, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. eduardovignoto@uel.br.
  • Hirooka EY; Department of Food Science and Technology, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. elisahirooka@hotmail.com.
  • Shimizu CF; Department of Food Science and Technology, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. cvsvetuel@gmail.com.
  • Oba A; Department of Zootechny, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. oba@uel.br.
  • Flaiban KKMC; Department of Preventive Veterinary Medicine, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. kkflaiban@uel.br.
  • Itano EN; Department of Pathologic Sciences, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. itano@uel.br.
Toxins (Basel) ; 11(5)2019 05 11.
Article em En | MEDLINE | ID: mdl-31083513
Ochratoxin A (OTA), an immunosuppressive mycotoxin, can increase the risk of many infectious diseases and contribute to economic losses to the poultry industry. The immunosuppressive effect has mainly been investigated through oral exposure; however, birds may also be contaminated through skin absorption. The present study investigated the influence of OTA exposure on the defense system of broiler chicks through the subcutaneous route and including low doses. Groups of broiler chicks (Cobb), 05 days old, were exposed to subcutaneous inoculation of OTA at concentrations of 0.1; 0.5; 0.9; 1.3; and 1.7 mg OTA/kg body weight. The size of the lymphoid organs, circulating immune cells, and total IgY and IgA levels were evaluated 21 days post inoculation. Subcutaneous OTA exposure decreased the weight of the thymus, spleen, and bursa of Fabricius, and leukocytopenia (p < 0.05) was detected in chicks of the OTA treated groups. In a dose-dependent way, decreased levels of circulating lymphocytes and heterophils (p < 0.05), and increased levels of monocytes (p < 0.05) were detected. Decreased IgY and IgA serum concentrations were noted in the OTA treated groups (p < 0.05). In conclusion, subcutaneous OTA exposure induces immunosuppression even at low levels.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Galinhas / Ocratoxinas Limite: Animals Idioma: En Revista: Toxins (Basel) Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Galinhas / Ocratoxinas Limite: Animals Idioma: En Revista: Toxins (Basel) Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça