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Virulence properties and sensitivity profile of Candida parapsilosis complex species and Kodamaea ohmeri isolates from onychomycosis of HIV/AIDS patients.
Ferreira, Erika Oliveira; Mendes, Iven Neylla Vale Farias; Monteiro, Sílvio Gomes; Crosara, Karla Tonelli Bicalho; Siqueira, Walter Luiz; de Maria Pedroso Silva de Azevedo, Conceição; Moffa, Eduardo Buozi; de Andrade Monteiro, Cristina.
Afiliação
  • Ferreira EO; Laboratório de Microbiologia Aplicada, Programa de Mestrado em Biologia Parasitária, Universidade Ceuma, São Luís, MA, Brazil.
  • Mendes INVF; Departamento de Biologia, Instituto Federal de Educação Tecnológica do Maranhão, São Luís, MA, Brazil.
  • Monteiro SG; Laboratório de Microbiologia Aplicada, Programa de Mestrado em Biologia Parasitária, Universidade Ceuma, São Luís, MA, Brazil.
  • Crosara KTB; School of Dentistry and Department of Biochemistry, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON, Canada.
  • Siqueira WL; School of Dentistry and Department of Biochemistry, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON, Canada.
  • de Maria Pedroso Silva de Azevedo C; Departamento de Medicina, Federal University of Maranhão, São Luis, MA, Brazil.
  • Moffa EB; Laboratório de Microbiologia Aplicada, Programa de Mestrado em Biologia Parasitária, Universidade Ceuma, São Luís, MA, Brazil; School of Dentistry and Department of Biochemistry, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON, Canada.
  • de Andrade Monteiro C; Laboratório de Microbiologia Aplicada, Programa de Mestrado em Biologia Parasitária, Universidade Ceuma, São Luís, MA, Brazil; Departamento de Biologia, Instituto Federal de Educação Tecnológica do Maranhão, São Luís, MA, Brazil. Electronic address: cristina.monteiro@ceuma.br.
Microb Pathog ; 132: 282-292, 2019 Jul.
Article em En | MEDLINE | ID: mdl-31082527
Cutaneous fungal infections include onychomycosis, an infection of the nail that affects both healthy and immunocompromised patients. This study investigated the in vitro hydrolytic enzymes production, adhesion and biofilm formation capacity of Candida parapsilosis complex species and Kodamaea ohmeri isolates from onychomycoses of HIV/AIDS patients and also established the antifungal sensitivity profiles of these isolates. Onychomycosis in HIV/AIDS patients showed a high prevalence of emerging yeasts, among which C. parapsilosis complex species and K. ohmeri were the most frequent. Three C. parapsilosis sensu stricto and two C. orthopsilosis isolates were resistant to amphotericin B and 83% of isolates were resistant to terbinafine. All three different species evaluated were proteinase and hemolysin producers. All isolates adhered to stainless steel and siliconized latex surfaces, and carbohydrates intensified adhesion of all isolates. Isolates adhered to keratinous nail and 50% formed biofilms with strong intensity. In multispecies or polymicrobial biofilms, C. albicans and Staphylococcus aureus regulated the biofilm formation of the analyzed species, decreasing the number of their cells in biofilms. The isolation of emerging yeast species from onychomycosis which are great producers of hydrolytic enzymes and with high adhesion and biofilm formation capacity is a result that should be considered relevant in clinical practice. In addition, half of the isolates was resistant to at least one of the tested antifungals. Taken together these data corroborate the infectious capacity and viability of these isolates under favorable conditions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome da Imunodeficiência Adquirida / Onicomicose / Saccharomycetales / Candida parapsilosis Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Microb Pathog Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome da Imunodeficiência Adquirida / Onicomicose / Saccharomycetales / Candida parapsilosis Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Microb Pathog Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido